Computational biology and bioinformatics

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

Featured

Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    As the climate warms, we can’t restore waterways to pristine condition, but models can predict potential changes, argue Jonathan D. Tonkin, N. LeRoy Poff and colleagues.

    • Jonathan D. Tonkin
    • , N. LeRoy Poff
    • , Nick R. Bond
    • , Avril Horne
    • , David. M. Merritt
    • , Lindsay V. Reynolds
    • , Julian D. Olden
    • , Albert Ruhi
    •  & David A. Lytle
    Nature 570, 301-303
  • News and Views |

    How do we recognize the individual faces of our family members, friends and acquaintances across the variation that is common in daily life? Zhan and colleagues demonstrate the importance of three-dimensional structure in the representations of known individuals and argue that texture—the surface properties of faces—plays little role in representation.

    • Nicholas Blauch
    •  & Marlene Behrmann
  • Comments and Opinion |

    Reproducibility and replicability are fundamental requirements of scientific studies. Disagreements over universal definitions for these terms have affected the interpretation of large-scale replication attempts. We provide a visual tool for representing definitions and use it to re-examine these attempts.

    • Prasad Patil
    • , Roger D. Peng
    •  & Jeffrey T. Leek
  • News and Views |

    Nature harnesses fractal geometry to create structures with unusual surface-to-volume ratios. Now, a new design approach enables the reversible assembly of functional enzymes into arboreal patterns with fractal geometry.

    • Iris D. Young
    •  & James S. Fraser