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| Open AccessSwitch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion
How do cells regulate their migration speed and direction? Here, authors discover that keratocyte cells can reversibly switch between different migration modes, by changing the 3D lamellipodium shape and intracellular diffusion.
- Chao Jiang
- , Hong-Yu Luo
- & Hui Li
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Article
| Open AccessCellular state landscape and herpes simplex virus type 1 infection progression are connected
The heterogeneity of single cell responses during infection have been reported to influence disease outcome. Here, Pietilä et al characterize cellular heterogeneity during Herpes Simplex Virus 1 infection using a multimodal approach that resolves gene expression, proteomic and spatial details at the single cell level.
- Maija K. Pietilä
- , Jana J. Bachmann
- & Cornel Fraefel
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Article
| Open AccessUniversal structures for adaptation in biochemical reaction networks
At the molecular level, the evolution of life is driven by the generation and diversification of adaptation mechanisms. Here Araujo and Liotta identify definitive and universal structural requirements for adaptation via intermolecular interactions.
- Robyn P. Araujo
- & Lance A. Liotta
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Perspective
| Open AccessAn aging, pathology burden, and glial senescence build-up hypothesis for late onset Alzheimer’s disease
In this perspective, the authors hypothesise that glial senescence, requiring senescent microglia burden, perpetuates further aging, Alzheimer’s pathologies, and senescence. Increasing glial senescence is proposed as necessary to drive individuals from healthy cognition into cognitive decline and dementia.
- Victor Lau
- , Leanne Ramer
- & Marie-Ève Tremblay
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Article
| Open AccessIncreases in reef size, habitat and metacommunity complexity associated with Cambrian radiation oxygenation pulses
During the Cambrian Radiation, oxygenation occurred in a series of short pulses. Here, the authors quantify episodic changes in reef size, extent of habitat and in metacommunity ecological complexity associated with these oxygenation pulses by examining archaeocyath sponges.
- Andrey Yu. Zhuravlev
- , Emily G. Mitchell
- & Amelia Penny
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Article
| Open AccessTwo simple movement mechanisms for spatial division of labour in social insects
Ant and honeybee workers specialize on certain tasks and also on zones within the nest; but how do they avoid straying into the wrong zone? The authors conduct automated tracking experiments following thousands of individuals, revealing that workers use context-dependent rules to navigate inside the nest.
- Thomas O. Richardson
- , Nathalie Stroeymeyt
- & Laurent Keller
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Article
| Open AccessA deeper understanding of system interactions can explain contradictory field results on pesticide impact on honey bees
Pesticide impact on honey bees under field conditions remains elusive. Here, the authors combine a systems biology approach and laboratory experiments to show that the immune suppressive effect of the pathogen deformed wing virus can be responsible for the disparity amongst honey bee experiments.
- Dimitri Breda
- , Davide Frizzera
- & Francesco Nazzi
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Article
| Open AccessModelling the medium-term dynamics of SARS-CoV-2 transmission in England in the Omicron era
This mathematical modelling study projects the dynamics of SARS-CoV-2 in England until the end of 2022 assuming that the Omicron BA.2 sublineage remains dominant. They show that booster vaccination was highly effective in mitigating severe outcomes and that future dynamics will depend greatly on assumptions about waning immunity.
- Rosanna C. Barnard
- , Nicholas G. Davies
- & W. John Edmunds
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Article
| Open AccessHysteresis stabilizes dynamic control of self-assembled army ant constructions
Army ant bridges are a remarkable example of self-assembled living structures. Here, the authors investigate experimentally how army ant bridges respond to unstable ground, revealing how responses emerge from the decentralized actions of individuals.
- Helen F. McCreery
- , Georgina Gemayel
- & Radhika Nagpal
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Article
| Open AccessSocial networks predict the life and death of honey bees
Honey bee workers take on different tasks for the colony as they age. Here, the authors develop a method to extract a descriptor of the individuals’ social networks and show that interaction patterns predict task allocation and distinguish different developmental trajectories.
- Benjamin Wild
- , David M. Dormagen
- & Tim Landgraf
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Article
| Open AccessHysteresis of tropical forests in the 21st century
Tropical rainforests partly create their own climatic conditions by promoting precipitation, therefore rainforest losses may trigger dramatic shifts. Here the authors combine remote sensing, hydrological modelling, and atmospheric moisture tracking simulations to assess forest-rainfall feedbacks in three major tropical rainforest regions on Earth and simulate potential changes under a severe climate change scenario.
- Arie Staal
- , Ingo Fetzer
- & Obbe A. Tuinenburg
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Article
| Open AccessDissection of gene expression datasets into clinically relevant interaction signatures via high-dimensional correlation maximization
Identification of clinically relevant gene expression signatures for cancer stratification remains challenging. Here, the authors introduce a flexible nonlinear signal superposition model that enables dissection of large gene expression data sets into signatures and extraction of gene interactions.
- Michael Grau
- , Georg Lenz
- & Peter Lenz
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Article
| Open AccessSurvival of the simplest in microbial evolution
In asexual populations selection at different genomic loci can interfere with each other. Here, using a biophysical model of molecular evolution the authors show that interference results in long-term degradation of molecular function, an effect that strongly depends on genome size.
- Torsten Held
- , Daniel Klemmer
- & Michael Lässig
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Article
| Open AccessThe topological requirements for robust perfect adaptation in networks of any size
Robust perfect adaptation (RPA), the ability of a system to return to its pre-stimulus state in the presence of a new signal, enables organisms to respond to further changes in stimuli. Here, the authors identify the modular structure of the full set of network topologies that can confer RPA on complex networks.
- Robyn P. Araujo
- & Lance A. Liotta
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Article
| Open AccessCrosstalk and the evolvability of intracellular communication
The evolutionary rationale behind the extensive crosstalk between Metazoan signalling pathways remains elusive. Here the authors provide evidence that crosstalk in the human signalling network evolves as a means to allow efficient diversification of cellular responses to the same signals between different cell types.
- Michael A. Rowland
- , Joseph M. Greenbaum
- & Eric J. Deeds
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Article
| Open AccessSingle-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome
Robust quantification of the differentiation potential of single cells is a task of great importance. Here the authors integrate single-cell RNA-Seq profiles with a cellular interaction network to compute the signaling entropy, and show that it can identify normal and cancer stem-cell phenotypes.
- Andrew E. Teschendorff
- & Tariq Enver