Complement

Complement is part of the innate immune system – comprising approximately 25 proteins and peptides – which is responsible for quickly and non-specifically sensing and responding to tissue alterations and pathogen antigens. Complement enhances recognition and destruction of antigens by attracting phagocytic cells such as macrophages and neutrophils and by triggering cytokine expression.

Latest Research and Reviews

  • Reviews |

    This Review covers new insights into the immune roles of complement. The authors discuss the pathways that link complement signalling with homeostatic and pathological T cell responses and highlight how complement components act intracellularly to shape T cell responses.

    • Edimara S. Reis
    • , Dimitrios C. Mastellos
    • , George Hajishengallis
    •  & John D. Lambris
  • Research | | open

    Antibodies against Plasmodium falciparum merozoites that fix complement can inhibit blood-stage replication. Here, Reiling et al. show that complement-fixing antibodies strongly correlate with protective immunity in children, identify the merozoite targets, and predict antigen combinations that should result in strong protection.

    • Linda Reiling
    • , Michelle J. Boyle
    • , Michael T. White
    • , Danny W. Wilson
    • , Gaoqian Feng
    • , Rupert Weaver
    • , D. Herbert Opi
    • , Kristina E. M. Persson
    • , Jack S. Richards
    • , Peter M. Siba
    • , Freya J. I. Fowkes
    • , Eizo Takashima
    • , Takafumi Tsuboi
    • , Ivo Mueller
    •  & James G. Beeson
  • Reviews |

    The complement system has a key role in inflammatory reactions that occur before, during and after transplantation. Here, the authors discuss this role and highlight current and future strategies to regulate complement activation and potentially improve outcomes in kidney transplantation.

    • Ali-Reza Biglarnia
    • , Markus Huber-Lang
    • , Camilla Mohlin
    • , Kristina N. Ekdahl
    •  & Bo Nilsson
  • Research | | open

    Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.

    • Mai Thi Nhu Tran
    • , Michito Hamada
    • , Hyojung Jeon
    • , Risako Shiraishi
    • , Keigo Asano
    • , Motochika Hattori
    • , Megumi Nakamura
    • , Yuki Imamura
    • , Yuki Tsunakawa
    • , Risa Fujii
    • , Toshiaki Usui
    • , Kaushalya Kulathunga
    • , Christina-Sylvia Andrea
    • , Ryusuke Koshida
    • , Risa Kamei
    • , Yurina Matsunaga
    • , Makoto Kobayashi
    • , Hisashi Oishi
    • , Takashi Kudo
    •  & Satoru Takahashi
  • Research | | open

    Complement C3a is an important protein in innate and adaptive immunity, but its roles in vivo are unclear. Here the authors develop novel chemical agonists and antagonists for the C3a receptor, and show that they modulate mast cell degranulation and inflammation in a rat paw edema model

    • Rink-Jan Lohman
    • , Johan K. Hamidon
    • , Robert C. Reid
    • , Jessica A. Rowley
    • , Mei-Kwan Yau
    • , Maria A. Halili
    • , Daniel S. Nielsen
    • , Junxian Lim
    • , Kai-Chen Wu
    • , Zhixuan Loh
    • , Anh Do
    • , Jacky Y. Suen
    • , Abishek Iyer
    •  & David P. Fairlie

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