Comparative genomics

Comparative genomics deals with the processes of evolution via the alignment and analysis of genes and genomes of living or extinct organisms related by varying degrees of evolutionary divergence from a common ancestor. Comparisons are usually made pairwise with reference to a third genome 'outgroup' or by examination of pairs of paired sequences and summarized in phylogenetic trees.

Latest Research and Reviews

News and Comment

  • News and Views |

    A new study used genome-wide association data and Mendelian randomization to investigate associations between the gut microbiome and metabolic traits. The researchers demonstrate that host genetic variants influence levels of the short-chain fatty acids butyrate and propionate in the gut, which in turn modulate host glycaemic metabolism.

    • Wei Ling Lau
    •  & Nosratola D. Vaziri
  • News and Views |

    Comparative analysis of microexons across bilaterians identifies a new protein domain associated with the evolutionary origin of microexon inclusion in neural tissues.

    • Rupert Faraway
    •  & Jernej Ule
  • News and Views |

    Magnoliid genomes provide novel insight into early angiosperm evolution, showing how whole-genome duplication and proliferation of transposable elements have shaped these genomes. Now, two papers giving differing views of early angiosperm phylogeny, raise questions about the relationships among eudicots, monocots and magnoliids.

    • Douglas E. Soltis
    •  & Pamela S. Soltis
    Nature Plants 5, 6-7
  • News and Views |

    The identification of a set of conserved genes that has had stable expression patterns over 120 million years of ant evolution provides a glimpse into the mechanisms that generate queen and worker castes in ants.

    • Sarah D. Kocher