Combinatorial libraries

Definition

Combinatorial libraries are collections of chemical compounds, small molecules or macromolecules such as proteins, synthesized by combinatorial chemistry, in which multiple different combinations of related chemical species are reacted together in similar chemical reactions. Chemical synthesis methods are used to generate large groups of compounds that can themselves be elaborated in a similar combinatorial fashion.

Latest Research and Reviews

News and Comment

  • News and Views |

    The quantitative self-assembly of mechanically interlocked molecules in water, instead of organic solvents, opens up the possibility of such systems being used in a biological context where their functions can be interfaced with biomolecular systems.

    • Linyi Bai
    •  & Yanli Zhao
    Nature Chemistry 7, 944–945
  • Comments and Opinion |

    Jeffrey Bode from ETH Zürich talks with Nature Chemistry about his group's work on synthetic fermentation, and how he hopes it could bring the power of chemical synthesis into the hands of citizen scientists.

    Nature Chemistry 6, 846–847
  • News and Views |

    The generation of chemical libraries for screening is a key part of the drug discovery process. Now, two studies describe attempts to combine features of natural product biosynthesis into the creation of libraries with the aim of mimicking nature's success at the production of bioactive molecules.

    • Derek B. Lowe
    Nature Chemistry 6, 851–852
  • News and Views |

    A high-throughput approach combining combinatorial deposition of materials with parallel blow-forming speeds up the discovery rate of bulk metallic glasses that can be easily formed into complex shapes.

    • Dan B. Miracle
    Nature Materials 13, 432–433