Collective cell migration articles from across Nature Portfolio

This Review discusses the complex mechanisms of wound healing — cell migration, matrix remodelling, inflammation and angiogenesis — and the contributions of different cell types, including immune cells, to this process. It also highlights new methodologies that could inform future therapies to prevent scarring and repair chronic wounds.

The mechanism underlying thyroid follicle formation is not well understood. Here, the authors show that a subgroup of NF-κB-activated thyrocytes, through interactions with myeloid cells, exhibit increased migration capacity to generate new follicles.

This mini review highlights and compares the principles of durotaxis and negative durotaxis as part of cell migratory processes.

Human sperm are shown to cooperate upon transit into high viscosity media with related sperm displaying higher tendencies to cooperate, suggesting sperm attachment is preferential and confers a benefit under inter-ejaculate conditions

A molecular pathway has been identified in the regulation of unjamming to overcome cancer cell migration and proliferation arrest leading to collective cell invasion.

Demonstration that active collective cell migration importantly contributes to the movement of intestinal epithelial cells along the villi.

A recent study published inNature Cell Biologyhas shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.

Microscale arrays of protein–polysaccharide clusters enable the functional characterization of human-neutrophil migration.

Mechanical coupling of cancer-associated fibroblasts and cancer cells through a heterotypic E-cadherin–N-cadherin adherens junction promotes cancer cell invasion.