Collapsing glomerulopathy

Definition

Collapsing glomerulopathy is a morphological variant of focal segmental glomerulosclerosis that is associated with a higher rate of progression to end-stage renal disease than other variants. It is characterized by segmental and total collapse of the glomerular capillaries, hypertrophy and hyperplasia of podocytes, and severe tubulointerstitial disease.

Latest Research and Reviews

  • Reviews |

    HIV infection is associated with renal diseases including HIV-associated nephropathy, HIV-immune-complex kidney disease, thrombotic microangiopathy and disorders associated with nephrotoxic HIV therapies. Here, the authors review the epidemiology, histopathology, mechanisms, genetic susceptibility, diagnosis and treatment of HIV-associated nephropathies and highlight remaining questions for future research.

    • Avi Z. Rosenberg
    • , Saraladevi Naicker
    • , Cheryl A. Winkler
    •  & Jeffrey B. Kopp

News and Comment

  • News and Views |

    Collapsing glomerulopathy, the classic kidney lesion in HIV-associated nephropathy, is characterized by the closure of glomerular capillary loops and epithelial cell proliferation. A new study shows that upregulation of TERT, the reverse transcriptase component of telomerase, in podocytes, the key filtration cells in the kidney, plays a major part in the development of this condition by activating Wnt signaling (pages 111–119).

    • Sumant S Chugh
    •  & Lionel C Clement
    Nature Medicine 18, 26–27