Cohesion between the duplicated DNA molecules keep them 'glued' together until they are separated in mitosis. Cohesion is mediated by the cohesin protein complex, and is destroyed in a highly regulated manner when chromosomes are correctly aligned to allow chromosome segregation into daughter cells.

Latest Research and Reviews

  • Research |

    Schalbetter et al. show by Hi-C and modelling that mitotic chromosome compaction in budding yeast occurs by cis-looping of chromatin, and reveal distinct roles for cohesin and condensin depending on chromatin context.

    • Stephanie Andrea Schalbetter
    • , Anton Goloborodko
    • , Geoffrey Fudenberg
    • , Jon-Matthew Belton
    • , Catrina Miles
    • , Miao Yu
    • , Job Dekker
    • , Leonid Mirny
    •  & Jonathan Baxter
    Nature Cell Biology 19, 1071–1080
  • Research | | open

    Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.

    • Rutger C. C. Hengeveld
    • , Martijn J. M. Vromans
    • , Mathijs Vleugel
    • , Michael A. Hadders
    •  & Susanne M. A. Lens
  • Research | | open

    Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesin ring.

    • Michael T. Hons
    • , Pim J. Huis in ‘t Veld
    • , Jan Kaesler
    • , Pascaline Rombaut
    • , Alexander Schleiffer
    • , Franz Herzog
    • , Holger Stark
    •  & Jan-Michael Peters
  • Reviews |

    SMC (structural maintenance of chromosomes) complexes are found in all living organisms and include condensin, cohesin and the SMC5–SMC6 complex. Recent mechanistic insight into these ring-shaped protein machines, which topologically encircle DNA, shed light on how they function to mediate chromosome condensation, sister chromatid cohesion and DNA repair.

    • Frank Uhlmann
  • Research |

    The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

    • Jihye Kim
    • , Kei-ichiro Ishiguro
    • , Aya Nambu
    • , Bungo Akiyoshi
    • , Shihori Yokobayashi
    • , Ayano Kagami
    • , Tadashi Ishiguro
    • , Alberto M. Pendas
    • , Naoki Takeda
    • , Yogo Sakakibara
    • , Tomoya S. Kitajima
    • , Yuji Tanno
    • , Takeshi Sakuno
    •  & Yoshinori Watanabe
    Nature 517, 466–471

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