Cohesion

Definition

Cohesion between the duplicated DNA molecules keep them 'glued' together until they are separated in mitosis. Cohesion is mediated by the cohesin protein complex, and is destroyed in a highly regulated manner when chromosomes are correctly aligned to allow chromosome segregation into daughter cells.

Latest Research and Reviews

  • Research | | open

    Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid cohesion. Here the authors rigidify cohesin using engineered Smc1 and Smc3 and generated 3D models showing how Pds5B forms an integral part of the cohesin ring.

    • Michael T. Hons
    • , Pim J. Huis in ‘t Veld
    • , Jan Kaesler
    • , Pascaline Rombaut
    • , Alexander Schleiffer
    • , Franz Herzog
    • , Holger Stark
    •  & Jan-Michael Peters
  • Reviews |

    SMC (structural maintenance of chromosomes) complexes are found in all living organisms and include condensin, cohesin and the SMC5–SMC6 complex. Recent mechanistic insight into these ring-shaped protein machines, which topologically encircle DNA, shed light on how they function to mediate chromosome condensation, sister chromatid cohesion and DNA repair.

    • Frank Uhlmann
  • Research |

    The long elusive mammalian meiosis-specific kinetochore factor has been identified in mice; MEIKIN—which plays an equivalent role to the yeast proteins Spo13 and Moa1—ensures mono-orientation, protects sister chromatid cohesion and recruits the kinase PLK1 to the kinetochores.

    • Jihye Kim
    • , Kei-ichiro Ishiguro
    • , Aya Nambu
    • , Bungo Akiyoshi
    • , Shihori Yokobayashi
    • , Ayano Kagami
    • , Tadashi Ishiguro
    • , Alberto M. Pendas
    • , Naoki Takeda
    • , Yogo Sakakibara
    • , Tomoya S. Kitajima
    • , Yuji Tanno
    • , Takeshi Sakuno
    •  & Yoshinori Watanabe
    Nature 517, 466–471
  • Research | | open

    Cohesion is associated with many forms of cancer. De Lange et al. show that such cohesion defects can sensitise cells to apoptosis in response to a new APC/C ubiquitin ligase inhibitor, by prolonging mitotic arrest and checkpoint activation due to cohesion fatigue.

    • Job de Lange
    • , Atiq Faramarz
    • , Anneke B. Oostra
    • , Renee X. de Menezes
    • , Ida H. van der Meulen
    • , Martin A. Rooimans
    • , Davy A. Rockx
    • , Ruud H. Brakenhoff
    • , Victor W. van Beusechem
    • , Randall W. King
    • , Johan P. de Winter
    •  & Rob M. F. Wolthuis
  • Reviews |

    Structural maintenance of chromosomes (SMC) complexes — cohesin, condensin and the SMC5/6 complex — regulate sister chromatid cohesion, chromosome condensation, and DNA replication, repair and transcription. Insights into how they may execute such a range of functions are emerging from analyses of their chromosomal binding, combined with their capacity to act as intermolecular and intramolecular linkers of DNA molecules.

    • Kristian Jeppsson
    • , Takaharu Kanno
    • , Katsuhiko Shirahige
    •  & Camilla Sjögren

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