Class switch recombination

Class switch recombination is a process by which proliferating B cells rearrange the constant region genes in the immunoglobulin heavy chain locus to switch from expressing one class of immunoglobulin (such as IgM) to another (such as IgG). This produces an antibody with different effector properties, without altering its antigen specificity.

Latest Research and Reviews

  • Reviews |

    Double-strand breaks in DNA generated during the normal assembly and diversification of lymphocyte antigen receptor genes or by genotoxic agents during infection activate DNA damage responses. Besides repairing damaged DNA, these responses trigger important signalling events that regulate immune cell development and function.

    • Jeffrey J. Bednarski
    •  & Barry P. Sleckman
  • Research | | open

    Activation-induced deaminase (AID) is important for inducing desirable mutations at the B cell receptor genes for effective antibody responses. Here the authors show that three key arginine residues of AID link AID-chromatin association with transcription elongation to license AID for specific mutagenesis in B cells.

    • Stephen P. Methot
    • , Ludivine C. Litzler
    • , Poorani Ganesh Subramani
    • , Anil K. Eranki
    • , Heather Fifield
    • , Anne-Marie Patenaude
    • , Julian C. Gilmore
    • , Gabriel E. Santiago
    • , Halil Bagci
    • , Jean-François Côté
    • , Mani Larijani
    • , Ramiro E. Verdun
    •  & Javier M. Di Noia
  • Research | | open

    Class switch recombination (CSR) requires break and repair of immunoglobulin DNA. Here the authors show that the histone deubiquitinase Usp22 is involved in V(D)J recombination and CSR of IgG and IgE, but not IgA, and that IgG CSR is dependent on the canonical c-NHEJ pathway, whereas IgA CSR is more dependent on the alternative A-EJ pathway.

    • Conglei Li
    • , Thergiory Irrazabal
    • , Clare C. So
    • , Maribel Berru
    • , Likun Du
    • , Evelyn Lam
    • , Alexanda K. Ling
    • , Jennifer L. Gommerman
    • , Qiang Pan-Hammarström
    •  & Alberto Martin
  • Research | | open

    Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.

    • Jordi Sintes
    • , Maurizio Gentile
    • , Shuling Zhang
    • , Yolanda Garcia-Carmona
    • , Giuliana Magri
    • , Linda Cassis
    • , Daniel Segura-Garzón
    • , Alessandra Ciociola
    • , Emilie K. Grasset
    • , Sabrina Bascones
    • , Laura Comerma
    • , Marc Pybus
    • , David Lligé
    • , Irene Puga
    • , Cindy Gutzeit
    • , Bing He
    • , Wendy DuBois
    • , Marta Crespo
    • , Julio Pascual
    • , Anna Mensa
    • , Juan Ignacio Aróstegui
    • , Manel Juan
    • , Jordi Yagüe
    • , Sergi Serrano
    • , Josep Lloreta
    • , Eric Meffre
    • , Michael Hahne
    • , Charlotte Cunningham-Rundles
    • , Beverly A. Mock
    •  & Andrea Cerutti

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