Chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL) is a progressive, malignant disease of the blood-forming organs, marked by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow.

Latest Research and Reviews

  • Research |

    • Andrea Visentin
    • , Laura Bonaldi
    • , Gian Matteo Rigolin
    • , Francesca Romana Mauro
    • , Annalisa Martines
    • , Federica Frezzato
    • , Silvia Imbergamo
    • , Edoardo Scomazzon
    • , Stefano Pravato
    • , Maria Antonella Bardi
    • , Maurizio Cavallari
    • , Eleonora Volta
    • , Francesco Cavazzini
    • , Maurizio Nanni
    • , Ilaria Del Giudice
    • , Monica Facco
    • , Anna Guarini
    • , Gianpietro Semenzato
    • , Robin Foà
    • , Antonio Cuneo
    •  & Livio Trentin
  • Research |

    Analysis of growth dynamics in a dataset from 107 patients with chronic lymphocytic leukaemia (CLL) reveals both exponential and logistic patterns of growth, which are associated with differences in genetic attributes and clinical outcomes.

    • Michaela Gruber
    • , Ivana Bozic
    • , Ignaty Leshchiner
    • , Dimitri Livitz
    • , Kristen Stevenson
    • , Laura Rassenti
    • , Daniel Rosebrock
    • , Amaro Taylor-Weiner
    • , Oriol Olive
    • , Reaha Goyetche
    • , Stacey M. Fernandes
    • , Jing Sun
    • , Chip Stewart
    • , Alicia Wong
    • , Carrie Cibulskis
    • , Wandi Zhang
    • , Johannes G. Reiter
    • , Jeffrey M. Gerold
    • , John G. Gribben
    • , Kanti R. Rai
    • , Michael J. Keating
    • , Jennifer R. Brown
    • , Donna Neuberg
    • , Thomas J. Kipps
    • , Martin A. Nowak
    • , Gad Getz
    •  & Catherine J. Wu
    Nature, 1-6
  • Research |

    A single-cell approach is used to follow the heritable stochastic changes to DNA methylation that occur in primary chronic lymphocytic leukaemia and healthy B cells, allowing the tracing of cell lineage histories and evolution during treatment with ibrutinib.

    • Federico Gaiti
    • , Ronan Chaligne
    • , Hongcang Gu
    • , Ryan M. Brand
    • , Steven Kothen-Hill
    • , Rafael C. Schulman
    • , Kirill Grigorev
    • , Davide Risso
    • , Kyu-Tae Kim
    • , Alessandro Pastore
    • , Kevin Y. Huang
    • , Alicia Alonso
    • , Caroline Sheridan
    • , Nathaniel D. Omans
    • , Evan Biederstedt
    • , Kendell Clement
    • , Lili Wang
    • , Joshua A. Felsenfeld
    • , Erica B. Bhavsar
    • , Martin J. Aryee
    • , John N. Allan
    • , Richard Furman
    • , Andreas Gnirke
    • , Catherine J. Wu
    • , Alexander Meissner
    •  & Dan A. Landau
    Nature 569, 576-580
  • Research | | open

    In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heterogeneity.

    • Alessandro Pastore
    • , Federico Gaiti
    • , Sydney X. Lu
    • , Ryan M. Brand
    • , Scott Kulm
    • , Ronan Chaligne
    • , Hongcang Gu
    • , Kevin Y. Huang
    • , Elena K. Stamenova
    • , Wendy Béguelin
    • , Yanwen Jiang
    • , Rafael C. Schulman
    • , Kyu-Tae Kim
    • , Alicia Alonso
    • , John N. Allan
    • , Richard R. Furman
    • , Andreas Gnirke
    • , Catherine J. Wu
    • , Ari M. Melnick
    • , Alexander Meissner
    • , Bradley E. Bernstein
    • , Omar Abdel-Wahab
    •  & Dan A. Landau

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