Chaperone-mediated autophagy

Definition

Chaperone-mediated autophagy is a type of autophagy in which individual cytosolic proteins are selectively targeted to the lysosome for degradation. Substrate proteins are recognised by a cytoplasmic chaperone protein that sends them to the lysosome membrane for subsequent import and degradation. Chaperone-mediated autophagy occurs without the formation of autophagosomes.

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