Cerebrospinal fluid proteins

Definition

Cerebrospinal fluid (CSF) proteins are proteins produced by ependymal cells in the choroid plexus of the brain and circulate through the CSF around and inside the brain and spinal cord. CSF proteins strengthen mechanically and provide immune protection for the brain. Diagnostic examination of CSF for its proteins can be useful in the clinic.

Latest Research and Reviews

  • Reviews |

    The elimination of amyloid-β (Aβ) from the brain is already impaired at the prodromal stage of Alzheimer disease (AD), so restoration of the clearance systems of the brain might delay the onset of AD. This Review provides a comprehensive update on the brain's clearance systems, including the recent discoveries of the glymphatic system and meningeal lymphatic vessels—findings that have important implications for understanding the disrupted elimination of toxic proteins in AD.

    • Jenna M. Tarasoff-Conway
    • , Roxana O. Carare
    • , Ricardo S. Osorio
    • , Lidia Glodzik
    • , Tracy Butler
    • , Els Fieremans
    • , Leon Axel
    • , Henry Rusinek
    • , Charles Nicholson
    • , Berislav V. Zlokovic
    • , Blas Frangione
    • , Kaj Blennow
    • , Joël Ménard
    • , Henrik Zetterberg
    • , Thomas Wisniewski
    •  & Mony J. de Leon
  • Research | | open

    Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes.

    • Scott Ayton
    • , Noel G. Faux
    • , Ashley I. Bush
    • , Alzheimer's Disease Neuroimaging Initiative
    • , Michael W. Weiner
    • , Paul Aisen
    • , Ronald Petersen
    • , Clifford R. Jack Jr.
    • , William Jagust
    • , John Q. Trojanowki
    • , Arthur W. Toga
    • , Laurel Beckett
    • , Robert C. Green
    • , Andrew J. Saykin
    • , John Morris
    • , Leslie M. Shaw
    • , Zaven Khachaturian
    • , Greg Sorensen
    • , Lew Kuller
    • , Marc Raichle
    • , Steven Paul
    • , Peter Davies
    • , Howard Fillit
    • , Franz Hefti
    • , Davie Holtzman
    • , M. Marcel Mesulam
    • , William Potter
    • , Peter Snyder
    • , Adam Schwartz
    • , Tom Montine
    • , Ronald G. Thomas
    • , Michael Donohue
    • , Sarah Walter
    • , Devon Gessert
    • , Tamie Sather
    • , Gus Jiminez
    • , Danielle Harvey
    • , Matthew Bernstein
    • , Nick Fox
    • , Paul Thompson
    • , Norbert Schuff
    • , Bret Borowski
    • , Jeff Gunter
    • , Matt Senjem
    • , Prashanthi Vemuri
    • , David Jones
    • , Kejal Kantarci
    • , Chad Ward
    • , Robert A. Koeppe
    • , Norm Foster
    • , Eric M. Reiman
    • , Kewei Chen
    • , Chet Mathis
    • , Susan Landau
    • , Nigel J. Cairns
    • , Erin Householder
    • , Lisa Taylor-Reinwald
    • , Virginia Lee
    • , Magdalena Korecka
    • , Michal Figurski
    • , Karen Crawford
    • , Scott Neu
    • , Tatiana M. Foroud
    • , Steven Potkin
    • , Li Shen
    • , Kelley Faber
    • , Sungeun Kim
    • , Kwangsik Nho
    • , Leon Thal
    • , Neil Buckholtz
    • , Marylyn Albert
    • , Richard Frank
    • , John Hsiao
    • , Jeffrey Kaye
    • , Joseph Quinn
    • , Betty Lind
    • , Raina Carter
    • , Sara Dolen
    • , Lon S. Schneider
    • , Sonia Pawluczyk
    • , Mauricio Beccera
    • , Liberty Teodoro
    • , Bryan M. Spann
    • , James Brewer
    • , Helen Vanderswag
    • , Adam Fleisher
    • , Judith L. Heidebrink
    • , Joanne L. Lord
    • , Sara S. Mason
    • , Colleen S. Albers
    • , David Knopman
    • , Kris Johnson
    • , Rachelle S. Doody
    • , Javier Villanueva-Meyer
    • , Munir Chowdhury
    • , Susan Rountree
    • , Mimi Dang
    • , Yaakov Stern
    • , Lawrence S. Honig
    • , Karen L. Bell
    • , Brittany Cerbone
    • , Reisa A. Sperling
    • , Allyson Rosen
    • , Paula Ogrocki
    • , Dino Massoglia
    • , Rob Bartha
    • , Daniel D’Agostino II
    • , Geoffrey Tremont
    • , Susan De Santi
    • , Andrew E. Budson
    • , Peggy Roberts
    • , Patricia Lynn Johnson
    • , Charles D. Smith
    • , Steven E. Arnold
    • , Jason H. Karlawish
    • , Richard King
    • , P. Murali Doraiswamy
    • , Lidia Glodzik
    • , Curtis Caldwell
    • , Raymundo Hernando
    • , Ellen Woo
    • , Kim Martin
    • , Walter Martinez
    • , T-Y Lee
    • , Ruth A. Mulnard
    • , Alan Lerner
    • , Chuang-Kuo Wu
    • , Nunzio Pomara
    • , Gail Li
    • , Kathleen Tingus
    • , Antero Sarrael
    • , Paul Malloy
    • , Catherine Mc-Adams-Ortiz
    • , Benita Mudge
    • , Bonnie S. Goldstein
    • , Stephen Salloway
    • , Andrew Kertesz
    • , Anahita Adeli
    • , Scott Herring
    • , James E. Galvin
    • , Franklin Watkins
    • , Kristine Lipowski
    • , Dana Nguyen
    • , Ging-Yuek Robin Hsiung
    • , Kelly M. Makino
    • , Karen Elizabeth Smith
    • , Allan I. Levey
    • , Erik Roberson
    • , Sandra A. Jacobson
    • , Janet S. Cellar
    • , Karl Friedl
    • , Howard Feldman
    • , Kaycee M. Sink
    • , Brandy R. Matthews
    • , Sanjay Asthana
    • , Vernice Bates
    • , Jeff D. Williamson
    • , Christina A. Michel
    • , Jeffrey M. Burns
    • , Meghan Frey
    • , Christopher H. van Dyck
    • , Ramon Diaz-Arrastia
    • , James J. Lah
    • , Barton Lane
    • , Heather Johnson
    • , Ann Marie Hake
    • , Horacio Capote
    • , Partha Sinha
    • , John Olichney
    • , Russell H. Swerdlow
    • , Melissa Davis
    • , Tracy Kendall
    • , Pradeep Garg
    • , Nancy Johnson
    • , Robert B. Santulli
    • , Kathleen Johnson
    • , Francine Parfitt
    • , Gloria Chaing
    • , David Bachman
    • , Raj C. Shah
    • , Jeffrey R. Petrella
    • , Kyle Womack
    • , Po H. Lu
    • , Jordan Grafman
    • , David Clark
    • , Daniel Varon
    • , Jared Tinklenberg
    • , Balebail Ashok Raj
    • , Leyla deToledo-Morrell
    • , Lisa Raudin
    • , Neil Kowall
    • , Kristin Fargher
    • , Mony J de Leon
    • , Debra Fleischman
    • , Elizabeth Oates
    • , Ansgar J. Furst
    • , David Geldmacher
    • , Terence Z. Wong
    • , MaryAnn Oakley
    • , Oscar L. Lopez
    • , Ranjan Duara
    • , Daniel H.S. Silverman
    • , David Wolk
    • , Sherye A. Sirrel
    • , Henry Querfurth
    • , Earl A. Zimmerman
    • , Amanda Smith
    • , Connie Brand
    • , Chiadi Onyike
    • , Karen Blank
    • , Elizabether Finger
    • , Teresa Villena
    • , Stacy Schneider
    • , Michael Borrie
    • , Effie Mitsis
    • , Joy L. Taylor
    • , Dzintra Celmins
    • , Steven G. Potkin
    • , Mark A. Mintun
    • , Charles DeCarli
    • , John Rogers
    • , Stephanie Reeder
    • , Henry Rusinek
    • , Christine M. Belden
    • , Bojana Stefanovic
    • , Charles Bernick
    • , George Bartzokis
    • , Randall Griffith
    • , Keith A. Johnson
    • , Neill R Graff-Radford
    • , Elaine R. Peskind
    • , Raymond Scott Turner
    • , Stephen Pasternak
    • , Mary Quiceno
    • , Ronald Killiany
    • , Sandra Black
    • , Pierre Tariot
    • , Gaby Thai
    • , Howard Bergman
    • , Donna M. Simpson
    • , Smita Kittur
    • , Martin R. Farlow
    • , Maria Carroll
    • , Peter Hardy
    • , Adrian Preda
    • , Hillel Grossman
    • , Dick Drost
    • , Eben S. Schwartz
    • , Sue Leon
    • , Michael DeVous
    • , Norman Relkin
    • , Godfrey D. Pearlson
    • , Susan K. Schultz
    • , Richard E. Carson
    • , Olga James
    • , Jacqueline Hayes
    • , Myron Weiner
    • , Beau Ances
    • , Stephanie Kielb
    • , Maria Kataki
    • , Stephen Correia
    • , Shannon Finley
    • , Konstantinos Arfanakis
    • , Douglas W. Scharre
    • , Leon Hudson
    • , Cynthia M. Carlsson
    • , Joanne Allard
    • , Evan Fletcher
    • , Irina Rachinsky
    • , John Brockington
    • , Michelle Rainka
    • , Thomas Neylan
    • , Owen Carmichael
    • , Greg Jicha
    • , Heather S. Anderson
    • , Martha G. MacAvoy
    • , Alice D. Brown
    • , Jerome A. Yesavage
    • , Alexander Norbash
    • , Gad Marshall
    • , Michele Assaly
    • , Angela Oliver
    • , Tamar J. Kitzmiller
    • , Diana Kerwin
    • , Daniel Marson
    • , J. Jay Fruehling
    • , Hyungsub Shim
    • , Marwan N. Sabbagh
    • , Karen Anderson
    • , M. Saleem Ismail
    • , Bruce L. Miller
    • , Rosemary Morrison
    • , Cynthia Hunt
    • , Gary Conrad
    • , Maria T. Greig
    • , Carl Sadowsky
    • , Brian R. Ott
    • , Marek-Marsel Mesulam
    • , Marilyn Albert
    • , Eric C. Petrie
    • , Donna Munic
    • , Jacobo Mintzer
    • , Kristen Martin-Cook
    • , Brigid Reynolds
    • , Kenneth Spicer
    • , Chris Hosein
    • , Howard J. Rosen
    • , Liana Apostolova
    • , Laura L. Boles Ponto
    • , Dana Mathews
    • , Sterling Johnson
    • , Anton P. Porsteinsson
    • , Sandra Harding
    •  & Howard Chertkow
  • Research |

    The spatial orientation of cell divisions is fundamental for tissue architecture and homeostasis but the extracellular cues regulating this process are largely unknown. Here, the authors show that Semaphorin3B released from the floor plate and the nascent choroid plexus controls progenitor division orientation in the developing mouse spinal cord.

    • Elise Arbeille
    • , Florie Reynaud
    • , Isabelle Sanyas
    • , Muriel Bozon
    • , Karine Kindbeiter
    • , Frédéric Causeret
    • , Alessandra Pierani
    • , Julien Falk
    • , Frédéric Moret
    •  & Valérie Castellani
  • Research |

    Ependymal cell cilia regulate cerebrospinal fluid flow through the cerebral ventricles. Here the authors show that the metabolic peptide melanin-concentrating hormone (MCH) increases cilia beat frequency in the third ventricle, and a lack of the MCH receptor increases ventricle size.

    • Grégory Conductier
    • , Frédéric Brau
    • , Angèle Viola
    • , Fanny Langlet
    • , Navean Ramkumar
    • , Bénédicte Dehouck
    • , Thibault Lemaire
    • , Raphaël Chapot
    • , Laurianne Lucas
    • , Carole Rovère
    • , Priscilla Maitre
    • , Salma Hosseiny
    • , Agnès Petit-Paitel
    • , Antoine Adamantidis
    • , Bernard Lakaye
    • , Pierre-Yves Risold
    • , Vincent Prévot
    • , Olivier Meste
    • , Jean-Louis Nahon
    •  & Alice Guyon
    Nature Neuroscience 16, 845–847

News and Comment