Cerebrospinal fluid proteins

Definition

Cerebrospinal fluid (CSF) proteins are proteins produced by ependymal cells in the choroid plexus of the brain and circulate through the CSF around and inside the brain and spinal cord. CSF proteins strengthen mechanically and provide immune protection for the brain. Diagnostic examination of CSF for its proteins can be useful in the clinic.

Latest Research and Reviews

  • Reviews |

    The elimination of amyloid-β (Aβ) from the brain is already impaired at the prodromal stage of Alzheimer disease (AD), so restoration of the clearance systems of the brain might delay the onset of AD. This Review provides a comprehensive update on the brain's clearance systems, including the recent discoveries of the glymphatic system and meningeal lymphatic vessels—findings that have important implications for understanding the disrupted elimination of toxic proteins in AD.

    • Jenna M. Tarasoff-Conway
    • , Roxana O. Carare
    • , Ricardo S. Osorio
    • , Lidia Glodzik
    • , Tracy Butler
    • , Els Fieremans
    • , Leon Axel
    • , Henry Rusinek
    • , Charles Nicholson
    • , Berislav V. Zlokovic
    • , Blas Frangione
    • , Kaj Blennow
    • , Joël Ménard
    • , Henrik Zetterberg
    • , Thomas Wisniewski
    •  & Mony J. de Leon
  • Research | | open

    Brain-iron elevation is implicated in Alzheimer’s disease (AD), but the impact of the metal on disease outcomes has not been analysed in a longitudinal study. Here, the authors examine the association between the levels of ferritin, an iron storage protein, in the cerebrospinal fluid (CSF) of AD patients and show that CSF ferritin levels predict AD outcomes.

    • Scott Ayton
    • , Noel G. Faux
    • , Ashley I. Bush
    • , Alzheimer's Disease Neuroimaging Initiative
    • , Michael W. Weiner
    • , Paul Aisen
    • , Ronald Petersen
    • , Clifford R. Jack Jr.
    • , William Jagust
    • , John Q. Trojanowki
    • , Arthur W. Toga
    • , Laurel Beckett
    • , Robert C. Green
    • , Andrew J. Saykin
    • , John Morris
    • , Leslie M. Shaw
    • , Zaven Khachaturian
    • , Greg Sorensen
    • , Lew Kuller
    • , Marc Raichle
    • , Steven Paul
    • , Peter Davies
    • , Howard Fillit
    • , Franz Hefti
    • , Davie Holtzman
    • , M. Marcel Mesulam
    • , William Potter
    • , Peter Snyder
    • , Adam Schwartz
    • , Tom Montine
    • , Ronald G. Thomas
    • , Michael Donohue
    • , Sarah Walter
    • , Devon Gessert
    • , Tamie Sather
    • , Gus Jiminez
    • , Danielle Harvey
    • , Matthew Bernstein
    • , Nick Fox
    • , Paul Thompson
    • , Norbert Schuff
    • , Bret Borowski
    • , Jeff Gunter
    • , Matt Senjem
    • , Prashanthi Vemuri
    • , David Jones
    • , Kejal Kantarci
    • , Chad Ward
    • , Robert A. Koeppe
    • , Norm Foster
    • , Eric M. Reiman
    • , Kewei Chen
    • , Chet Mathis
    • , Susan Landau
    • , Nigel J. Cairns
    • , Erin Householder
    • , Lisa Taylor-Reinwald
    • , Virginia Lee
    • , Magdalena Korecka
    • , Michal Figurski
    • , Karen Crawford
    • , Scott Neu
    • , Tatiana M. Foroud
    • , Steven Potkin
    • , Li Shen
    • , Kelley Faber
    • , Sungeun Kim
    • , Kwangsik Nho
    • , Leon Thal
    • , Neil Buckholtz
    • , Marylyn Albert
    • , Richard Frank
    • , John Hsiao
    • , Jeffrey Kaye
    • , Joseph Quinn
    • , Betty Lind
    • , Raina Carter
    • , Sara Dolen
    • , Lon S. Schneider
    • , Sonia Pawluczyk
    • , Mauricio Beccera
    • , Liberty Teodoro
    • , Bryan M. Spann
    • , James Brewer
    • , Helen Vanderswag
    • , Adam Fleisher
    • , Judith L. Heidebrink
    • , Joanne L. Lord
    • , Sara S. Mason
    • , Colleen S. Albers
    • , David Knopman
    • , Kris Johnson
    • , Rachelle S. Doody
    • , Javier Villanueva-Meyer
    • , Munir Chowdhury
    • , Susan Rountree
    • , Mimi Dang
    • , Yaakov Stern
    • , Lawrence S. Honig
    • , Karen L. Bell
    • , Beau Ances
    • , Maria Carroll
    • , Sue Leon
    • , Mark A. Mintun
    • , Stacy Schneider
    • , Angela Oliver
    • , Daniel Marson
    • , Randall Griffith
    • , David Clark
    • , David Geldmacher
    • , John Brockington
    • , Erik Roberson
    • , Hillel Grossman
    • , Effie Mitsis
    • , Leyla deToledo-Morrell
    • , Raj C. Shah
    • , Ranjan Duara
    • , Daniel Varon
    • , Maria T. Greig
    • , Peggy Roberts
    • , Marilyn Albert
    • , Chiadi Onyike
    • , Daniel D’Agostino II
    • , Stephanie Kielb
    • , James E. Galvin
    • , Brittany Cerbone
    • , Christina A. Michel
    • , Henry Rusinek
    • , Mony J de Leon
    • , Lidia Glodzik
    • , Susan De Santi
    • , P. Murali Doraiswamy
    • , Jeffrey R. Petrella
    • , Terence Z. Wong
    • , Steven E. Arnold
    • , Jason H. Karlawish
    • , David Wolk
    • , Charles D. Smith
    • , Greg Jicha
    • , Peter Hardy
    • , Partha Sinha
    • , Elizabeth Oates
    • , Gary Conrad
    • , Oscar L. Lopez
    • , MaryAnn Oakley
    • , Donna M. Simpson
    • , Anton P. Porsteinsson
    • , Bonnie S. Goldstein
    • , Kim Martin
    • , Kelly M. Makino
    • , M. Saleem Ismail
    • , Connie Brand
    • , Ruth A. Mulnard
    • , Gaby Thai
    • , Catherine Mc-Adams-Ortiz
    • , Kyle Womack
    • , Dana Mathews
    • , Mary Quiceno
    • , Ramon Diaz-Arrastia
    • , Richard King
    • , Myron Weiner
    • , Kristen Martin-Cook
    • , Michael DeVous
    • , Allan I. Levey
    • , James J. Lah
    • , Janet S. Cellar
    • , Jeffrey M. Burns
    • , Heather S. Anderson
    • , Russell H. Swerdlow
    • , Liana Apostolova
    • , Kathleen Tingus
    • , Ellen Woo
    • , Daniel H.S. Silverman
    • , Po H. Lu
    • , George Bartzokis
    • , Neill R Graff-Radford
    • , Francine Parfitt
    • , Tracy Kendall
    • , Heather Johnson
    • , Martin R. Farlow
    • , Ann Marie Hake
    • , Brandy R. Matthews
    • , Scott Herring
    • , Cynthia Hunt
    • , Christopher H. van Dyck
    • , Richard E. Carson
    • , Martha G. MacAvoy
    • , Howard Chertkow
    • , Howard Bergman
    • , Chris Hosein
    • , Sandra Black
    • , Bojana Stefanovic
    • , Curtis Caldwell
    • , Ging-Yuek Robin Hsiung
    • , Howard Feldman
    • , Benita Mudge
    • , Michele Assaly
    • , Andrew Kertesz
    • , John Rogers
    • , Charles Bernick
    • , Donna Munic
    • , Diana Kerwin
    • , Marek-Marsel Mesulam
    • , Kristine Lipowski
    • , Chuang-Kuo Wu
    • , Nancy Johnson
    • , Carl Sadowsky
    • , Walter Martinez
    • , Teresa Villena
    • , Raymond Scott Turner
    • , Kathleen Johnson
    • , Brigid Reynolds
    • , Reisa A. Sperling
    • , Keith A. Johnson
    • , Gad Marshall
    • , Meghan Frey
    • , Barton Lane
    • , Allyson Rosen
    • , Jared Tinklenberg
    • , Marwan N. Sabbagh
    • , Christine M. Belden
    • , Sandra A. Jacobson
    • , Sherye A. Sirrel
    • , Neil Kowall
    • , Ronald Killiany
    • , Andrew E. Budson
    • , Alexander Norbash
    • , Patricia Lynn Johnson
    • , Joanne Allard
    • , Alan Lerner
    • , Paula Ogrocki
    • , Leon Hudson
    • , Evan Fletcher
    • , Owen Carmichael
    • , John Olichney
    • , Charles DeCarli
    • , Smita Kittur
    • , Michael Borrie
    • , T-Y Lee
    • , Rob Bartha
    • , Sterling Johnson
    • , Sanjay Asthana
    • , Cynthia M. Carlsson
    • , Steven G. Potkin
    • , Adrian Preda
    • , Dana Nguyen
    • , Pierre Tariot
    • , Stephanie Reeder
    • , Vernice Bates
    • , Horacio Capote
    • , Michelle Rainka
    • , Douglas W. Scharre
    • , Maria Kataki
    • , Anahita Adeli
    • , Earl A. Zimmerman
    • , Dzintra Celmins
    • , Alice D. Brown
    • , Godfrey D. Pearlson
    • , Karen Blank
    • , Karen Anderson
    • , Robert B. Santulli
    • , Tamar J. Kitzmiller
    • , Eben S. Schwartz
    • , Kaycee M. Sink
    • , Jeff D. Williamson
    • , Pradeep Garg
    • , Franklin Watkins
    • , Brian R. Ott
    • , Henry Querfurth
    • , Geoffrey Tremont
    • , Stephen Salloway
    • , Paul Malloy
    • , Stephen Correia
    • , Howard J. Rosen
    • , Bruce L. Miller
    • , Jacobo Mintzer
    • , Kenneth Spicer
    • , David Bachman
    • , Elizabether Finger
    • , Stephen Pasternak
    • , Irina Rachinsky
    • , Dick Drost
    • , Nunzio Pomara
    • , Raymundo Hernando
    • , Antero Sarrael
    • , Susan K. Schultz
    • , Laura L. Boles Ponto
    • , Hyungsub Shim
    • , Karen Elizabeth Smith
    • , Norman Relkin
    • , Gloria Chaing
    • , Lisa Raudin
    • , Amanda Smith
    • , Kristin Fargher
    • , Balebail Ashok Raj
    • , Thomas Neylan
    • , Jordan Grafman
    • , Melissa Davis
    • , Rosemary Morrison
    • , Jacqueline Hayes
    • , Shannon Finley
    • , Karl Friedl
    • , Debra Fleischman
    • , Konstantinos Arfanakis
    • , Olga James
    • , Dino Massoglia
    • , J. Jay Fruehling
    • , Sandra Harding
    • , Elaine R. Peskind
    • , Eric C. Petrie
    • , Gail Li
    • , Jerome A. Yesavage
    • , Joy L. Taylor
    •  & Ansgar J. Furst
  • Research |

    Ependymal cell cilia regulate cerebrospinal fluid flow through the cerebral ventricles. Here the authors show that the metabolic peptide melanin-concentrating hormone (MCH) increases cilia beat frequency in the third ventricle, and a lack of the MCH receptor increases ventricle size.

    • Grégory Conductier
    • , Frédéric Brau
    • , Angèle Viola
    • , Fanny Langlet
    • , Navean Ramkumar
    • , Bénédicte Dehouck
    • , Thibault Lemaire
    • , Raphaël Chapot
    • , Laurianne Lucas
    • , Carole Rovère
    • , Priscilla Maitre
    • , Salma Hosseiny
    • , Agnès Petit-Paitel
    • , Antoine Adamantidis
    • , Bernard Lakaye
    • , Pierre-Yves Risold
    • , Vincent Prévot
    • , Olivier Meste
    • , Jean-Louis Nahon
    •  & Alice Guyon
    Nature Neuroscience 16, 845–847
  • Research |

    The spatial orientation of cell divisions is fundamental for tissue architecture and homeostasis but the extracellular cues regulating this process are largely unknown. Here, the authors show that Semaphorin3B released from the floor plate and the nascent choroid plexus controls progenitor division orientation in the developing mouse spinal cord.

    • Elise Arbeille
    • , Florie Reynaud
    • , Isabelle Sanyas
    • , Muriel Bozon
    • , Karine Kindbeiter
    • , Frédéric Causeret
    • , Alessandra Pierani
    • , Julien Falk
    • , Frédéric Moret
    •  & Valérie Castellani

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