Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Central nervous system infections include bacterial and aseptic (typically viral) meningitis, viral and autoimmune encephalitis and myelitis, which targets the spinal cord.
SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle interference with normal synaptic transmission.
In comparison to PeV-A1, infection with PeV-A3 is associated with neurological illness in infants. Here, using brain organoids, the authors suggest that the innate inflammatory response as the underlying reason, and not replication kinetics.
Autonomic nervous system dysregulation contributes to the chronic, debilitating disorders referred to as ‘long COVID’ or post-acute sequelae of SARS-CoV-2 infection (PASC). Here, Goldstein describes a multisystem, multidisciplinary approach to understanding PASC-induced alterations in feedback-regulated, plastic networks that determine homeostasis and allostasis.
SARS-CoV-2 infection can be associated with ‘brain fog’ and persistent neurologic disease, especially in the elderly, with the possibility of direct viral particle interference with normal synaptic transmission.
New research shows that meningeal lymphatic vessels can drain viruses from the CNS, with important implications for our understanding of CNS infections.
Several studies indicate that, in individuals infected with herpes simplex virus and/or varicella zoster virus, antiviral therapy reduces the subsequent risk of Alzheimer disease and other types of dementia. As highlighted in this article, the preventative potential of antiviral therapy would probably be maximized by treating asymptomatic as well as symptomatic infected individuals.
