Cellular signalling networks

Cellular signalling networks are formed when different cell signalling pathways interact and are detected by a combination of experimental and computational methods. Understanding how a biological system responds to a signal can be deduced by analysing how multiple cell signalling pathways affect each other and, in turn, cellular processes within the network.

Latest Research and Reviews

  • Research | | open

    Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights the involvement of the immune system in disease pathogenesis.

    • Lohith Madireddy
    • , Niklaos A. Patsopoulos
    • , Chris Cotsapas
    • , Steffan D. Bos
    • , Ashley Beecham
    • , Jacob McCauley
    • , Kicheol Kim
    • , Xiaoming Jia
    • , Adam Santaniello
    • , Stacy J. Caillier
    • , Till F. M. Andlauer
    • , Lisa F. Barcellos
    • , Tone Berge
    • , Luisa Bernardinelli
    • , Filippo Martinelli-Boneschi
    • , David R. Booth
    • , Farren Briggs
    • , Elisabeth G. Celius
    • , Manuel Comabella
    • , Giancarlo Comi
    • , Bruce A. C. Cree
    • , Sandra D’Alfonso
    • , Katrina Dedham
    • , Pierre Duquette
    • , Dardiotis Efthimios
    • , Federica Esposito
    • , Bertrand Fontaine
    • , Christiane Gasperi
    • , An Goris
    • , Bénédicte Dubois
    • , Pierre-Antoine Gourraud
    • , Georgios Hadjigeorgiou
    • , Jonathan Haines
    • , Clive Hawkins
    • , Bernhard Hemmer
    • , Rogier Hintzen
    • , Dana Horakova
    • , Noriko Isobe
    • , Seema Kalra
    • , Jun-ichi Kira
    • , Michael Khalil
    • , Ingrid Kockum
    • , Christina M. Lill
    • , Matthew R. Lincoln
    • , Felix Luessi
    • , Roland Martin
    • , Annette Oturai
    • , Aarno Palotie
    • , Margaret A. Pericak-Vance
    • , Roland Henry
    • , Janna Saarela
    • , Adrian Ivinson
    • , Tomas Olsson
    • , Bruce V. Taylor
    • , Graeme J. Stewart
    • , Hanne F. Harbo
    • , Alastair Compston
    • , Stephen L. Hauser
    • , David A. Hafler
    • , Frauke Zipp
    • , Philip De Jager
    • , Stephen Sawcer
    • , Jorge R. Oksenberg
    •  & Sergio E. Baranzini
  • Research | | open

    Synergistic interactions may arise between regulators in complex molecular networks. Here, the authors develop OptiCon, a computational method for de novo identification of synergistic key regulators and investigate their potential roles as candidate targets for combination therapy.

    • Yuxuan Hu
    • , Chia-hui Chen
    • , Yang-yang Ding
    • , Xiao Wen
    • , Bingbo Wang
    • , Lin Gao
    •  & Kai Tan
  • Research | | open

    Protein phosphorylation has various regulatory functions. Here, the authors map 241 phosphorylation hotspot regions across 40 eukaryotic species, showing that they are enriched at interfaces and near catalytic residues, and enable the discovery of functionally important phospho-sites.

    • Marta J. Strumillo
    • , Michaela Oplová
    • , Cristina Viéitez
    • , David Ochoa
    • , Mohammed Shahraz
    • , Bede P. Busby
    • , Richelle Sopko
    • , Romain A. Studer
    • , Norbert Perrimon
    • , Vikram G. Panse
    •  & Pedro Beltrao
  • Research | | open

    With the increasing obtainability of multi-OMICs data comes the need for easy to use data analysis tools. Here, the authors introduce Metascape, a biologist-oriented portal that provides a gene list annotation, enrichment and interactome resource and enables integrated analysis of multi-OMICs datasets.

    • Yingyao Zhou
    • , Bin Zhou
    • , Lars Pache
    • , Max Chang
    • , Alireza Hadj Khodabakhshi
    • , Olga Tanaseichuk
    • , Christopher Benner
    •  & Sumit K. Chanda

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