Cell type diversity

Definition

Cell type diversity refers to the range of different cell types that comprise a tissue or organism. Cell type diversity arises during the development of the nervous system as a result of the acts of cell intrinsic and extrinsic factors controlling cell fate determination.

Latest Research and Reviews

  • Research |

    Combinatorial inputs from temporal and spatial axes act together to promote medullary neural diversity in the optic lobes of Drosophila.

    • Ted Erclik
    • , Xin Li
    • , Maximilien Courgeon
    • , Claire Bertet
    • , Zhenqing Chen
    • , Ryan Baumert
    • , June Ng
    • , Clara Koo
    • , Urfa Arain
    • , Rudy Behnia
    • , Alberto Del Valle Rodriguez
    • , Lionel Senderowicz
    • , Nicolas Negre
    • , Kevin P. White
    •  & Claude Desplan
    Nature 541, 365–370
  • Research | | open

    Ependymal cells lining the adult brain ventricles are comprised of multiciliated cells and a rare subpopulation with two cilia (E2 cells) whose origin and function remain unknown. Here the authors find E2 cells in the 3rd ventricle of mice and humans, along with a third ependymal cell type with only a primary cilium, and provide details of their marker profile and developmental origins.

    • Zaman Mirzadeh
    • , Yael Kusne
    • , Maria Duran-Moreno
    • , Elaine Cabrales
    • , Sara Gil-Perotin
    • , Christian Ortiz
    • , Bin Chen
    • , Jose Manuel Garcia-Verdugo
    • , Nader Sanai
    •  & Arturo Alvarez-Buylla
  • Reviews |

    Emerging evidence suggests that astrocytes may be as diverse in their physiological and functional characteristics as neurons. Ben Haim and Rowitch describe astrocyte heterogeneity, consider the mechanisms by which such diversity may arise and discuss the consequences of its disruption in disease.

    • Lucile Ben Haim
    •  & David H. Rowitch
  • Research |

    The sympathetic system maintains a physiological balance, adjusts bodily functions during daily living activities, and can activate stress responses. The authors identify a variety of unique sympathetic neuronal types and show that the system is highly organized with dedicated neurons organized into discrete outflow channels for specific bodily functions.

    • Alessandro Furlan
    • , Gioele La Manno
    • , Moritz Lübke
    • , Martin Häring
    • , Hind Abdo
    • , Hannah Hochgerner
    • , Jussi Kupari
    • , Dmitry Usoskin
    • , Matti S Airaksinen
    • , Guillermo Oliver
    • , Sten Linnarsson
    •  & Patrik Ernfors
    Nature Neuroscience 19, 1331–1340

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