Cell transplantation


Cell transplantation is a procedure in which cells, often stem cells or cells that can be induced to become pluripotent stem cells, are transferred to a site where the tissue is damaged or diseased. The transfer can occur within an individual (autologous transplantation), between individuals, or between species. Cells can be treated before implantation.

Latest Research and Reviews

  • Research | | open

    Islet transplantation is considered one of the potential treatments for T1DM but limited islet survival and their impaired function pose limitations to this approach. Here Loh et al. show that the Y1 receptor is expressed in β- cells and inhibition of its signalling, both genetic and pharmacological, improves mouse and human islet function.

    • Kim Loh
    • , Yan-Chuan Shi
    • , Stacey Walters
    • , Mohammed Bensellam
    • , Kailun Lee
    • , Katsuya Dezaki
    • , Masanori Nakata
    • , Chi Kin Ip
    • , Jeng Yie Chan
    • , Esteban N. Gurzov
    • , Helen E. Thomas
    • , Michaela Waibel
    • , James Cantley
    • , Thomas W. Kay
    • , Toshihiko Yada
    • , D. Ross Laybutt
    • , Shane T. Grey
    •  & Herbert Herzog
  • Reviews |

    Autologous haematopoietic stem cell transplantation has produced striking results in patients with aggressive multiple sclerosis in small trials. In this Review, Muraro et al. provide an overview of the procedure, detail evidence for its high efficacy in multiple sclerosis, and provide recommendations for its clinical use and future trials.

    • Paolo A. Muraro
    • , Roland Martin
    • , Giovanni Luigi Mancardi
    • , Richard Nicholas
    • , Maria Pia Sormani
    •  & Riccardo Saccardi
  • Reviews |

    Islet transplantation has become a realistic treatment option for a subset of patients with type 1 diabetes mellitus. This Review outlines the techniques involved in the procedure, as well as the risks, long-term outcomes and advances in the care of patients after they have received an islet transplant.

    • A. M. James Shapiro
    • , Marta Pokrywczynska
    •  & Camillo Ricordi
  • Reviews |

    Systemic lupus erythematosus is an autoimmune disease that can affect many organs, including the skin, joints, the central nervous system and the kidneys. Here, Kaul et al. highlight the heterogeneity of the disease, the management approaches and provide an outlook on the future research directions.

    • Arvind Kaul
    • , Caroline Gordon
    • , Mary K. Crow
    • , Zahi Touma
    • , Murray B. Urowitz
    • , Ronald van Vollenhoven
    • , Guillermo Ruiz-Irastorza
    •  & Graham Hughes
  • Reviews |

    Advances in the derivation of pluripotent stem cells (PSCs) and their differentiation to specific cell types could have diverse clinical applications. Trounson and DeWitt provide an overview of the progress in using embryonic stem cell and induced PSC derivatives for disease treatment and discuss the potential and limitations of such approaches.

    • Alan Trounson
    •  & Natalie D. DeWitt

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