Cell signalling

Definition

Cell signalling is the mechanism by which stimuli are transmitted via a signalling cascade to effector molecules that orchestrate the appropriate response. Types of cell signalling pathways include checkpoint signalling, lipid signalling, growth signalling, nutrient signalling, insulin signalling, stress signalling, morphogen signalling, Hippo signalling, TOR signalling and integrin signalling.

Latest Research and Reviews

  • Research | | open

    mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains.

    • Ryo Yonehara
    • , Shigeyuki Nada
    • , Tomokazu Nakai
    • , Masahiro Nakai
    • , Ayaka Kitamura
    • , Akira Ogawa
    • , Hirokazu Nakatsumi
    • , Keiichi I. Nakayama
    • , Songling Li
    • , Daron M. Standley
    • , Eiki Yamashita
    • , Atsushi Nakagawa
    •  & Masato Okada
  • Research | | open

    The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • , Thiago S. Mosqueiro
    • , Brian J. Archer
    • , William M. Jones
    • , Hannah Sunshine
    • , Guido C. Faas
    • , Anais Briot
    • , Raquel L. Aragón
    • , Trent Su
    • , Milagros C. Romay
    • , Austin I. McDonald
    • , Cheng-Hsiang Kuo
    • , Carlos O. Lizama
    • , Timothy F. Lane
    • , Ann C. Zovein
    • , Yun Fang
    • , Elizabeth J. Tarling
    • , Thomas Q. de Aguiar Vallim
    • , Mohamad Navab
    • , Alan M. Fogelman
    • , Louis S. Bouchard
    •  & M. Luisa Iruela-Arispe
  • Research | | open

    The chemokine receptor CXCR3-A is expressed in high grade glioma. Here the authors show that CXCR3-A interacts with LPR1, a protein highly expressed in glioma, and this interaction regulates the trafficking of the receptor ultimately impacting on tumour cell migration.

    • Kevin Boyé
    • , Nadège Pujol
    • , Isabel D Alves
    • , Ya-Ping Chen
    • , Thomas Daubon
    • , Yi-Zong Lee
    • , Stephane Dedieu
    • , Marion Constantin
    • , Lorenzo Bello
    • , Marco Rossi
    • , Rolf Bjerkvig
    • , Shih-Che Sue
    • , Andreas Bikfalvi
    •  & Clotilde Billottet
  • Research | | open

    Macroautophagy can regulate cell signalling and tumorigenesis but the molecular mechanisms are unclear. Here the authors show selective degradation of the signalling scaffold TRAF3 by autophagy and consequent activation of the NF-κB family member RELB regulate gene expression via antagonism of SMAD proteins.

    • Alice C. Newman
    • , Alain J. Kemp
    • , Yvette Drabsch
    • , Christian Behrends
    •  & Simon Wilkinson
  • Reviews |

    In this Review, Woldu and colleagues describe the implications of Rho GTPase signalling aberrations in the development of malignancy, including urothelial carcinoma. This signalling pathway has the potential for therapeutic targeting in this disease, but much work is necessary before current laboratory-based research can be translated into the clinic.

    • Solomon L. Woldu
    • , Ryan C. Hutchinson
    • , Laura-Maria Krabbe
    • , Oner Sanli
    •  & Vitaly Margulis
  • Reviews |

    In this Review, the authors describe the role of the NO–sGC–cGMP signalling pathway in disease pathophysiology of urogenital tissue. They discuss advances in directly targeting sGC to enhance cGMP production independently using NO-independent stimulators and activators of sGC and the potential of these molecules for treating urogenital disorders.

    • Fabiola Z. Mónica
    •  & Edson Antunes

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