Cell polarity

Cell polarity is the asymmetric organisation of several cellular components, including its plasma membrane, cytoskeleton or organelles. This asymmetry can be used for specialised functions, such as maintaining a barrier within an epithelium or transmitting signals in neurons.

Latest Research and Reviews

News and Comment

  • News and Views |

    Epithelial–mesenchymal transition (EMT) is crucial for development, and for dissemination and invasion of cancer cells. A study now identifies the apical–basolateral polarity status of epithelia as a checkpoint for EMT induction and tumour metastasis through aPKC–Par3-regulated degradation of the EMT transcription factor SNAI1.

    • Oana-Diana Persa
    •  & Carien M. Niessen
    Nature Cell Biology 21, 299-300
  • Comments and Opinion |

    Sandrine Etienne-Manneville investigates the molecular mechanisms underlying cell migration in health and disease. She is Head of the Cell Polarity, Migration and Cancer laboratory, Director of the CNRS UMR3691 unit at the Institut Pasteur, Paris, France, a professor of cell biology and a mother of four.

    • Sandrine Etienne-Manneville
  • Research Highlights |

    A recent study published in Nature Cell Biology has shown that tumour spheres that maintain an inverted epithelial architecture originate from primary colorectal cancers and can collectively invade the peritoneum, initiating metastasis.

    • Sarah Seton-Rogers
  • News and Views |

    Cytoplasmic flows are essential for various cellular processes. However, tools to manipulate these flows within cells are still lacking. Now research shows that an optical tool allows for control of cytoplasmic flows and can be used as a subcellular rheometer.

    • Karsten Kruse
    • , Nicolas Chiaruttini
    •  & Aurélien Roux
    Nature Cell Biology 20, 227-228