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Cell growth usually refers to cell proliferation, the increase in cell numbers that occurs through repeated cell division. Cell growth can also refer to the enlargement of cell volume, which can take place in the absence of cell division.
This protocol describes how to produce cell-derived matrices from fibroblasts. These matrices can be used to provide a 3D scaffold for cell culture and to investigate cell behavior in complex microenvironments.
The 2017 Albert Lasker Basic Medical Research Award was awarded to Michael N. Hall (Biozentrum, University of Basel, Switzerland) “for discoveries concerning the nutrient-activated TOR proteins and their central role in the metabolic control of cell growth”.