Cell fate and cell lineage


A cell’s lineage describes the developmental history of a cell from its birth until its final division and differentiation into a particular cell type, which is known as its cell fate. Cell fate is determined by the actions of numerous cell intrinsic and extrinsic factors.

Latest Research and Reviews

  • Protocols |

    CellNet is a computational platform designed to improve cell fate engineering protocols. Here the authors demonstrate how to apply CellNet to RNA-seq data and how to build a completely new CellNet platform applicable to new species or cell types/tissues.

    • Arthur H Radley
    • , Remy M Schwab
    • , Yuqi Tan
    • , Jeesoo Kim
    • , Emily K W Lo
    •  & Patrick Cahan
    Nature Protocols 12, 1089–1102
  • Research |

    Shi et al. performed a systematic clonal analysis and revealed an intricate ontogenetic logic of structural development and functional organization of the mammalian thalamus. Notably, neurons in cognitive versus sensory or motor nuclei as well as in first-order versus high-order sensory or motor nuclei across different modalities exhibit distinct progenitor origin and spatial configuration.

    • Wei Shi
    • , Anjin Xianyu
    • , Zhi Han
    • , Xing Tang
    • , Zhizhong Li
    • , Haining Zhong
    • , Tianyi Mao
    • , Kun Huang
    •  & Song-Hai Shi
    Nature Neuroscience 20, 516–528
  • Research | | open

    Ependymal cells lining the adult brain ventricles are comprised of multiciliated cells and a rare subpopulation with two cilia (E2 cells) whose origin and function remain unknown. Here the authors find E2 cells in the 3rd ventricle of mice and humans, along with a third ependymal cell type with only a primary cilium, and provide details of their marker profile and developmental origins.

    • Zaman Mirzadeh
    • , Yael Kusne
    • , Maria Duran-Moreno
    • , Elaine Cabrales
    • , Sara Gil-Perotin
    • , Christian Ortiz
    • , Bin Chen
    • , Jose Manuel Garcia-Verdugo
    • , Nader Sanai
    •  & Arturo Alvarez-Buylla
  • Research | | open

    The development and function of thalamic interneurons is only partially understood. Here the authors describe the unexpected mesencephalic origin of the GABAergic interneurons of the visual thalamus that provide both phasic and tonic modulation of thalamic relay neuron excitability.

    • Polona Jager
    • , Zhiwen Ye
    • , Xiao Yu
    • , Laskaro Zagoraiou
    • , Hong-Ting Prekop
    • , Juha Partanen
    • , Thomas M. Jessell
    • , William Wisden
    • , Stephen G. Brickley
    •  & Alessio Delogu

News and Comment