Cell death

Cell death terminates normal cellular functions, including respiration, metabolism, growth and proliferation. Cell death can be non-programmed, for example as the result of accidental injury or trauma, or programmed. Types of programmed cell death include anoikis, apoptosis, autophagy, necrosis, necroptosis and pyroptosis.

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Latest Research and Reviews

  • Research | | open

    Autophagic activity decreases with age via unknown mechanisms. Here the authors show that expression of the negative autophagy regulator Rubicon increases with age, that its genetic ablation improves lifespan and ameliorates a number of age-associated phenotypes in invertebrates and in mouse models.

    • Shuhei Nakamura
    • , Masaki Oba
    • , Mari Suzuki
    • , Atsushi Takahashi
    • , Tadashi Yamamuro
    • , Mari Fujiwara
    • , Kensuke Ikenaka
    • , Satoshi Minami
    • , Namine Tabata
    • , Kenichi Yamamoto
    • , Sayaka Kubo
    • , Ayaka Tokumura
    • , Kanako Akamatsu
    • , Yumi Miyazaki
    • , Tsuyoshi Kawabata
    • , Maho Hamasaki
    • , Koji Fukui
    • , Kazunori Sango
    • , Yoshihisa Watanabe
    • , Yoshitsugu Takabatake
    • , Tomoya S. Kitajima
    • , Yukinori Okada
    • , Hideki Mochizuki
    • , Yoshitaka Isaka
    • , Adam Antebi
    •  & Tamotsu Yoshimori
  • Research | | open

    Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple organisms by inducing autophagy.

    • Didac Carmona-Gutierrez
    • , Andreas Zimmermann
    • , Katharina Kainz
    • , Federico Pietrocola
    • , Guo Chen
    • , Silvia Maglioni
    • , Alfonso Schiavi
    • , Jihoon Nah
    • , Sara Mertel
    • , Christine B. Beuschel
    • , Francesca Castoldi
    • , Valentina Sica
    • , Gert Trausinger
    • , Reingard Raml
    • , Cornelia Sommer
    • , Sabrina Schroeder
    • , Sebastian J. Hofer
    • , Maria A. Bauer
    • , Tobias Pendl
    • , Jelena Tadic
    • , Christopher Dammbrueck
    • , Zehan Hu
    • , Christoph Ruckenstuhl
    • , Tobias Eisenberg
    • , Sylvere Durand
    • , Noélie Bossut
    • , Fanny Aprahamian
    • , Mahmoud Abdellatif
    • , Simon Sedej
    • , David P. Enot
    • , Heimo Wolinski
    • , Jörn Dengjel
    • , Oliver Kepp
    • , Christoph Magnes
    • , Frank Sinner
    • , Thomas R. Pieber
    • , Junichi Sadoshima
    • , Natascia Ventura
    • , Stephan J. Sigrist
    • , Guido Kroemer
    •  & Frank Madeo
  • Research |

    Lystad et al. identify distinct membrane binding regions in ATG16L1 and show that the β-isoform-specific C-terminal region is required for VPS34/ULK1/2-independent non-canonical autophagy.

    • Alf Håkon Lystad
    • , Sven R. Carlsson
    • , Laura R. de la Ballina
    • , Karlina J. Kauffman
    • , Shanta Nag
    • , Tamotsu Yoshimori
    • , Thomas J. Melia
    •  & Anne Simonsen

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