Cell biology

Definition

Cell biology is the discipline of biological sciences that studies the structure, physiology, growth, reproduction and death of cells. Research in cell biology uses microscopic and molecular tools and examines all cell types, from unicellular organisms such as protozoa to the specialised cells that consitutute multicellular organisms.

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Latest Research and Reviews

  • Reviews |

    Lysosomal storage disorders (LSDs) are rare, inherited metabolic disorders that result from defects in lysosomal function, for which treatment options are limited. Here, Platt provides an overview of LSDs, approved and potential therapeutic approaches and agents currently in development. The challenges associated with LSD diagnosis, drug development and treatment are discussed.

    • Frances M. Platt
  • Reviews |

    Sphingolipids, specifically ceramide and sphingosine-1-phosphate, have opposing roles in regulating cancer cell death and survival, respectively. This Review discusses the mechanistic and clinical studies of sphingolipid signalling and metabolism in cancer, highlighting current and emerging therapeutic strategies to target these bioactive lipids.

    • Besim Ogretmen
  • Research | | open

    Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.

    • Pamela P. Lee
    • , Damián Lobato-Márquez
    • , Nayani Pramanik
    • , Andrea Sirianni
    • , Vanessa Daza-Cajigal
    • , Elizabeth Rivers
    • , Alessia Cavazza
    • , Gerben Bouma
    • , Dale Moulding
    • , Kjell Hultenby
    • , Lisa S. Westerberg
    • , Michael Hollinshead
    • , Yu-Lung Lau
    • , Siobhan O. Burns
    • , Serge Mostowy
    • , Mona Bajaj-Elliott
    •  & Adrian J. Thrasher
  • Research | | open

    Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.

    • Rose Willett
    • , José A. Martina
    • , James P. Zewe
    • , Rachel Wills
    • , Gerald R. V. Hammond
    •  & Rosa Puertollano

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