CD8-positive T cells

Definition

CD8-positive T cells are a critical subpopulation of MHC class I-restricted T cell and are mediators of adaptive immunity. They include cytotoxic T cells, which are important for killing cancerous or virally infected cells, and CD8-positive suppressor T cells, which restrain certain types of immune response.

Latest Research and Reviews

  • Research | | open

    Dengue virus-specific antibody and CD8+ T cells that cross-react with Zika virus have been described. Here, the authors establish a functionally protective role for cross-reactive dengue virus-specific CD8+ T cells during challenge with Zika virus.

    • Jinsheng Wen
    • , Annie Elong Ngono
    • , Jose Angel Regla-Nava
    • , Kenneth Kim
    • , Matthew J. Gorman
    • , Michael S. Diamond
    •  & Sujan Shresta
  • Research | | open

    IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour response.

    • Qinghong Wang
    • , Huan Ning
    • , Hui Peng
    • , Lin Wei
    • , Rong Hou
    • , Daniel F. Hoft
    •  & Jianguo Liu
  • Research |

    T cells developing in the thymus are signaled during positive selection to differentiate into either CD4+ T cells or CD8+ T cells. Singer and colleagues show that CD8+-lineage specification is signaled exclusively by cytokines, including cytokines that do not signal via the γc receptor, and that these are the only signals in the thymus that upregulate the transcription factor Runx3d to direct specification to the CD8+ lineage.

    • Ruth Etzensperger
    • , Tejas Kadakia
    • , Xuguang Tai
    • , Amala Alag
    • , Terry I Guinter
    • , Takeshi Egawa
    • , Batu Erman
    •  & Alfred Singer
    Nature Immunology 18, 1218–1227
  • Research | | open

    NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal response to bacteria and tumor cells.

    • Stefan Klein-Hessling
    • , Khalid Muhammad
    • , Matthias Klein
    • , Tobias Pusch
    • , Ronald Rudolf
    • , Jessica Flöter
    • , Musga Qureischi
    • , Andreas Beilhack
    • , Martin Vaeth
    • , Carsten Kummerow
    • , Christian Backes
    • , Rouven Schoppmeyer
    • , Ulrike Hahn
    • , Markus Hoth
    • , Tobias Bopp
    • , Friederike Berberich-Siebelt
    • , Amiya Patra
    • , Andris Avots
    • , Nora Müller
    • , Almut Schulze
    •  & Edgar Serfling
  • Protocols |

    This protocol describes an optimized procedure for retroviral (RV) transduction of mouse T cells by enriching RV-susceptible activated CD8+ T cells through Percoll density centrifugation, enhancing the frequency of RV-transduced cells sixfold in vivo.

    • Makoto Kurachi
    • , Junko Kurachi
    • , Zeyu Chen
    • , John Johnson
    • , Omar Khan
    • , Bertram Bengsch
    • , Erietta Stelekati
    • , John Attanasio
    • , Laura M McLane
    • , Michio Tomura
    • , Satoshi Ueha
    •  & E John Wherry
    Nature Protocols 12, 1980–1998
  • Research | | open

    Grail is an E3 ubiquitin ligase that inhibits T-cell receptor signalling in CD4+ T cells. Here the authors show Grail also limits IL-21 receptor expression and function in CD8+ T cells, is overactive in these cells in patients with lymphoma, and promotes tumour development in a lymphoma transplant mouse model.

    • Cara Haymaker
    • , Yi Yang
    • , Junmei Wang
    • , Qiang Zou
    • , Anupama Sahoo
    • , Andrei Alekseev
    • , Divyendu Singh
    • , Krit Ritthipichai
    • , Yared Hailemichael
    • , Oanh N. Hoang
    • , Hong Qin
    • , Kimberly S. Schluns
    • , Tiejun Wang
    • , Willem W. Overwijk
    • , Shao-Cong Sun
    • , Chantale Bernatchez
    • , Larry W. Kwak
    • , Sattva S. Neelapu
    •  & Roza Nurieva

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