CD4-positive T cells

Definition

CD4-positive T cells are a subtype of lymphocyte. They are MHC class II-restricted and are important mediators of adaptive immunity. These cells are involved in both the induction and the restraint of most immunological functions. A key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T cell.

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Latest Research and Reviews

  • Research | | open

    Chronic graft-versus-host disease (cGVHD) is mediated by specific CD4 and B cells, but the relative contribution of extrafollicular and germinal centre (GC) T-B interaction is unclear. Here the authors show that the extrafollicular expansion of a specific CD4 T subset is sufficient for inducing cGVHD while GC is dispensable.

    • Ruishu Deng
    • , Christian Hurtz
    • , Qingxiao Song
    • , Chanyu Yue
    • , Gang Xiao
    • , Hua Yu
    • , Xiwei Wu
    • , Markus Muschen
    • , Stephen Forman
    • , Paul J. Martin
    •  & Defu Zeng
  • Research | | open

    Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or PI3Kδ reveals alternative transplant survival outcomes post CTLA4-Ig treatment.

    • Mayuko Uehara
    • , Martina M. McGrath
    • , Shunsuke Ohori
    • , Zhabiz Solhjou
    • , Naima Banouni
    • , Sujit Routray
    • , Catherine Evans
    • , Jonathan P. DiNitto
    • , Abdallah Elkhal
    • , Laurence A. Turka
    • , Terry B. Strom
    • , Stefan G. Tullius
    • , David G. Winkler
    • , Jamil Azzi
    •  & Reza Abdi
  • Research | | open

    The transcription factor Foxo1 can control regulatory T cell and Th1 function. Here the authors show that Foxo1 is also critical for IL-9 production by Th9 cells and other IL-9-producing cells.

    • Sakshi Malik
    • , Srikanth Sadhu
    • , Srikanth Elesela
    • , Ramendra Pati Pandey
    • , Amanpreet Singh Chawla
    • , Deepak Sharma
    • , Lipsa Panda
    • , Deepak Rathore
    • , Balram Ghosh
    • , Vineet Ahuja
    •  & Amit Awasthi
  • Research | | open

    Developmental cues for the different dendritic cell (DC) subsets in the intestine are yet to be defined. Here the authors show that TGFβR1 signalling is needed for development of CD103+CD11b+ intestinal DCs from CD103CD11b+ cells and that they contribute to the generation of Th17 and regulatory T cells

    • C. C. Bain
    • , J. Montgomery
    • , C. L. Scott
    • , J. M. Kel
    • , M. J. H. Girard-Madoux
    • , L. Martens
    • , T. F. P. Zangerle-Murray
    • , J. Ober-Blöbaum
    • , D. Lindenbergh-Kortleve
    • , J. N. Samsom
    • , S. Henri
    • , T. Lawrence
    • , Y. Saeys
    • , B. Malissen
    • , M. Dalod
    • , B. E. Clausen
    •  & A. McI. Mowat

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