Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Cardiovascular models are experimental systems that recreate aspects of human cardiovascular development, function or disease. They can include experimental, genetic or transgenic systems in animals such as the rat, mouse, pig, rabbit and zebrafish.
This protocol differentiates hPSCs into self-renewing epicardial cells by appropriate differentiation-stage-specific application of Gsk3 inhibitor, Wnt inhibitor, and then Gsk3 inhibitor again in a completely defined, xeno-free system.
A new study shows that the prebiotic inulin improves vascular function in an animal model of cardiovascular disease. A key mechanism for how dietary gut microbiota modulation regulates host physiology through the activities of host–microbiota co-metabolic signalling via bile acids and glucagon-like peptide 1 is also explained.
Harvard researchers have developed an organ on a chip that recapitulates genetic, morphological and functional markers of failing myocardium. The system could help identify therapeutic candidates that slow or reverse heart failure with better reliability than current in vitro culture systems.