Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Cardiovascular models are experimental systems that recreate aspects of human cardiovascular development, function or disease. They can include experimental, genetic or transgenic systems in animals such as the rat, mouse, pig, rabbit and zebrafish.
Expandable and multipotent induced cardiac progenitor cells (iCPCs) are generated from mouse adult fibroblasts using forced expression of Mesp1, Tbx5, Gata4, Nkx2.5 and Baf60c and activation of the Wnt and JAK/STAT signaling pathway. Furthermore, embryonic potency of iCPCs is tested ex vivo.
Harvard researchers have developed an organ on a chip that recapitulates genetic, morphological and functional markers of failing myocardium. The system could help identify therapeutic candidates that slow or reverse heart failure with better reliability than current in vitro culture systems.