Cardiovascular genetics

Definition

Cardiovascular genetics is the study of the genetic mechanisms of cardiovascular physiology and pathophysiology.

Latest Research and Reviews

  • Research | | open

    Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.

    • Ilja M. Nolte
    • , M. Loretto Munoz
    • , Vinicius Tragante
    • , Azmeraw T. Amare
    • , Rick Jansen
    • , Ahmad Vaez
    • , Benedikt von der Heyde
    • , Christy L. Avery
    • , Joshua C. Bis
    • , Bram Dierckx
    • , Jenny van Dongen
    • , Stephanie M. Gogarten
    • , Philippe Goyette
    • , Jussi Hernesniemi
    • , Ville Huikari
    • , Shih-Jen Hwang
    • , Deepali Jaju
    • , Kathleen F. Kerr
    • , Alexander Kluttig
    • , Bouwe P. Krijthe
    • , Jitender Kumar
    • , Sander W. van der Laan
    • , Leo-Pekka Lyytikäinen
    • , Adam X. Maihofer
    • , Arpi Minassian
    • , Peter J. van der Most
    • , Martina Müller-Nurasyid
    • , Michel Nivard
    • , Erika Salvi
    • , James D. Stewart
    • , Julian F. Thayer
    • , Niek Verweij
    • , Andrew Wong
    • , Delilah Zabaneh
    • , Mohammad H. Zafarmand
    • , Abdel Abdellaoui
    • , Sulayma Albarwani
    • , Christine Albert
    • , Alvaro Alonso
    • , Foram Ashar
    • , Juha Auvinen
    • , Tomas Axelsson
    • , Dewleen G. Baker
    • , Paul I. W. de Bakker
    • , Matteo Barcella
    • , Riad Bayoumi
    • , Rob J. Bieringa
    • , Dorret Boomsma
    • , Gabrielle Boucher
    • , Annie R. Britton
    • , Ingrid Christophersen
    • , Andrea Dietrich
    • , George B. Ehret
    • , Patrick T. Ellinor
    • , Markku Eskola
    • , Janine F. Felix
    • , John S. Floras
    • , Oscar H. Franco
    • , Peter Friberg
    • , Maaike G. J. Gademan
    • , Mark A. Geyer
    • , Vilmantas Giedraitis
    • , Catharina A. Hartman
    • , Daiane Hemerich
    • , Albert Hofman
    • , Jouke-Jan Hottenga
    • , Heikki Huikuri
    • , Nina Hutri-Kähönen
    • , Xavier Jouven
    • , Juhani Junttila
    • , Markus Juonala
    • , Antti M. Kiviniemi
    • , Jan A. Kors
    • , Meena Kumari
    • , Tatiana Kuznetsova
    • , Cathy C. Laurie
    • , Joop D. Lefrandt
    • , Yong Li
    • , Yun Li
    • , Duanping Liao
    • , Marian C. Limacher
    • , Henry J. Lin
    • , Cecilia M. Lindgren
    • , Steven A. Lubitz
    • , Anubha Mahajan
    • , Barbara McKnight
    • , Henriette Meyer zu Schwabedissen
    • , Yuri Milaneschi
    • , Nina Mononen
    • , Andrew P. Morris
    • , Mike A. Nalls
    • , Gerjan Navis
    • , Melanie Neijts
    • , Kjell Nikus
    • , Kari E. North
    • , Daniel T. O'Connor
    • , Johan Ormel
    • , Siegfried Perz
    • , Annette Peters
    • , Bruce M. Psaty
    • , Chris J. O'Donnell
    • , Arie M. van Roon
    • , Tanja G. M. Vrijkotte
    • , Jessica van Setten
    • , Timothy A. Thornton
    • , Mika Kähönen
    • , Folkert W. Asselbergs
    • , Eco J. C. de Geus
    • , Michele K. Evans
    • , Mohammad Hassan
    • , Jan A. Staessen
    • , Pim van der Harst
    • , Halina K. Greiser
    • , Nicholas L. Smith
    • , Susan R. Heckbert
    • , Stefan Kääb
    • , John D. Rioux
    • , Eric A. Whitsel
    • , Gonneke Willemsen
    • , Alexander Teumer
    • , David Siscovick
    • , Charles Kooperberg
    • , Cees A. Swenne
    • , Katarzyna Stolarz-Skrzypek
    • , Johannes H. Smit
    • , Alan B. Zonderman
    • , Jean-Claude Tardif
    • , Moritz F. Sinner
    • , Jerome I. Rotter
    • , Kirk C. Wilhelmsen
    • , Marjo-Riitta Järvelin
    • , Quenna Wong
    • , Caroline M. Nievergelt
    • , Nona Sotoodehnia
    • , Tamar Sofer
    • , Marcel den Hoed
    • , Johan Sundström
    • , Andreas Voss
    • , Konstantin Strauch
    • , Bianca J. J. M. Brundel
    • , André G. Uitterlinden
    • , Elsayed Z. Soliman
    • , Ann-Christine Syvänen
    • , Harold Snieder
    • , Erik Ingelsson
    • , Zhu-Ming Zhang
    • , Terho Lehtimäki
    • , Mika Kivimaki
    • , Brenda Penninx
    • , Victoria B. Risbrough
    • , Kent D. Taylor
    • , Bruno H. Stricker
    • , Lars Lind
    • , Melanie Waldenberger
    • , Alexander P. Reiner
    • , Harriëtte Riese
    • , Daniele Cusi
    • , Olli T. Raitakari
    • , Lesley E. Tinker
    • , Henning Tiemeier
    • , Albertine J. Oldehinkel
    • , Adrienne M. Stilp
    • , Phyllis K. Stein
    •  & Diana Kuh
  • Research | | open

    Bicuspid aortic valve (BAV) is the most common human congenital cardiovascular malformation. Here, the authors perform a genome-wide association study for BAV and identify risk variants in the gene region of cardiac-specific transcription factor GATA4 and implicate GATA4 in heart valve development.

    • Bo Yang
    • , Wei Zhou
    • , Jiao Jiao
    • , Jonas B. Nielsen
    • , Michael R. Mathis
    • , Mahyar Heydarpour
    • , Guillaume Lettre
    • , Lasse Folkersen
    • , Siddharth Prakash
    • , Claudia Schurmann
    • , Lars Fritsche
    • , Gregory A. Farnum
    • , Maoxuan Lin
    • , Mohammad Othman
    • , Whitney Hornsby
    • , Anisa Driscoll
    • , Alexandra Levasseur
    • , Marc Thomas
    • , Linda Farhat
    • , Marie-Pierre Dubé
    • , Eric M. Isselbacher
    • , Anders Franco-Cereceda
    • , Dong-chuan Guo
    • , Erwin P. Bottinger
    • , G. Michael Deeb
    • , Anna Booher
    • , Sachin Kheterpal
    • , Y. Eugene Chen
    • , Hyun Min Kang
    • , Jacob Kitzman
    • , Heather J. Cordell
    • , Bernard D. Keavney
    • , Judith A. Goodship
    • , Santhi K. Ganesh
    • , Gonçalo Abecasis
    • , Kim A. Eagle
    • , Alan P. Boyle
    • , Ruth J. F. Loos
    • , Per Eriksson
    • , Jean-Claude Tardif
    • , Chad M. Brummett
    • , Dianna M. Milewicz
    • , Simon C. Body
    •  & Cristen J. Willer

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