Cardiovascular genetics

Definition

Cardiovascular genetics is the study of the genetic mechanisms of cardiovascular physiology and pathophysiology.

Latest Research and Reviews

  • Reviews |

    HDL-cholesterol levels in plasma predict the risk of cardiovascular disease, but a direct causal role for HDL in cardiovascular disease remains controversial. In this Review, Rosenson et al. discuss the opportunities afforded by an integrated approach that combines human genetic studies with systems biology to understand the complex metabolism of HDL and its potential atheroprotective properties.

    • Robert S. Rosenson
    • , H. Bryan Brewer Jr
    • , Philip J. Barter
    • , Johan L. M. Björkegren
    • , M. John Chapman
    • , Daniel Gaudet
    • , Daniel Seung Kim
    • , Eric Niesor
    • , Kerry-Anne Rye
    • , Frank M. Sacks
    • , Jean-Claude Tardif
    •  & Robert A. Hegele
  • Research | | open

    It is believed that mutations in desmosomal adhesion complex protein plakophilin 2 (PKP2) cause arrhythmia due to loss of cell-cell communication. Here the authors show that PKP2 controls the expression of proteins involved in calcium cycling in adult mouse hearts, and that lack of PKP2 can cause arrhythmia in a structurally normal heart.

    • Marina Cerrone
    • , Jerome Montnach
    • , Xianming Lin
    • , Yan-Ting Zhao
    • , Mingliang Zhang
    • , Esperanza Agullo-Pascual
    • , Alejandra Leo-Macias
    • , Francisco J. Alvarado
    • , Igor Dolgalev
    • , Thomas V. Karathanos
    • , Kabir Malkani
    • , Chantal J.M. Van Opbergen
    • , Joanne J.A. van Bavel
    • , Hua-Qian Yang
    • , Carolina Vasquez
    • , David Tester
    • , Steven Fowler
    • , Fengxia Liang
    • , Eli Rothenberg
    • , Adriana Heguy
    • , Gregory E. Morley
    • , William A. Coetzee
    • , Natalia A. Trayanova
    • , Michael J. Ackerman
    • , Toon A.B. van Veen
    • , Hector H. Valdivia
    •  & Mario Delmar
  • Research | | open

    Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.

    • Ilja M. Nolte
    • , M. Loretto Munoz
    • , Vinicius Tragante
    • , Azmeraw T. Amare
    • , Rick Jansen
    • , Ahmad Vaez
    • , Benedikt von der Heyde
    • , Christy L. Avery
    • , Joshua C. Bis
    • , Bram Dierckx
    • , Jenny van Dongen
    • , Stephanie M. Gogarten
    • , Philippe Goyette
    • , Jussi Hernesniemi
    • , Ville Huikari
    • , Shih-Jen Hwang
    • , Deepali Jaju
    • , Kathleen F. Kerr
    • , Alexander Kluttig
    • , Bouwe P. Krijthe
    • , Jitender Kumar
    • , Sander W. van der Laan
    • , Leo-Pekka Lyytikäinen
    • , Adam X. Maihofer
    • , Arpi Minassian
    • , Peter J. van der Most
    • , Martina Müller-Nurasyid
    • , Michel Nivard
    • , Erika Salvi
    • , James D. Stewart
    • , Julian F. Thayer
    • , Niek Verweij
    • , Andrew Wong
    • , Delilah Zabaneh
    • , Mohammad H. Zafarmand
    • , Abdel Abdellaoui
    • , Sulayma Albarwani
    • , Christine Albert
    • , Alvaro Alonso
    • , Foram Ashar
    • , Juha Auvinen
    • , Tomas Axelsson
    • , Dewleen G. Baker
    • , Paul I. W. de Bakker
    • , Matteo Barcella
    • , Riad Bayoumi
    • , Rob J. Bieringa
    • , Dorret Boomsma
    • , Gabrielle Boucher
    • , Annie R. Britton
    • , Ingrid Christophersen
    • , Andrea Dietrich
    • , George B. Ehret
    • , Patrick T. Ellinor
    • , Markku Eskola
    • , Janine F. Felix
    • , John S. Floras
    • , Oscar H. Franco
    • , Peter Friberg
    • , Maaike G. J. Gademan
    • , Mark A. Geyer
    • , Vilmantas Giedraitis
    • , Catharina A. Hartman
    • , Daiane Hemerich
    • , Albert Hofman
    • , Jouke-Jan Hottenga
    • , Heikki Huikuri
    • , Nina Hutri-Kähönen
    • , Xavier Jouven
    • , Juhani Junttila
    • , Markus Juonala
    • , Antti M. Kiviniemi
    • , Jan A. Kors
    • , Meena Kumari
    • , Tatiana Kuznetsova
    • , Cathy C. Laurie
    • , Joop D. Lefrandt
    • , Yong Li
    • , Yun Li
    • , Duanping Liao
    • , Marian C. Limacher
    • , Henry J. Lin
    • , Cecilia M. Lindgren
    • , Steven A. Lubitz
    • , Anubha Mahajan
    • , Barbara McKnight
    • , Henriette Meyer zu Schwabedissen
    • , Yuri Milaneschi
    • , Nina Mononen
    • , Andrew P. Morris
    • , Mike A. Nalls
    • , Gerjan Navis
    • , Melanie Neijts
    • , Kjell Nikus
    • , Kari E. North
    • , Daniel T. O'Connor
    • , Johan Ormel
    • , Siegfried Perz
    • , Annette Peters
    • , Bruce M. Psaty
    • , Chris J. O'Donnell
    • , Arie M. van Roon
    • , Tanja G. M. Vrijkotte
    • , Jessica van Setten
    • , Timothy A. Thornton
    • , Mika Kähönen
    • , Folkert W. Asselbergs
    • , Eco J. C. de Geus
    • , Michele K. Evans
    • , Mohammad Hassan
    • , Jan A. Staessen
    • , Pim van der Harst
    • , Halina K. Greiser
    • , Nicholas L. Smith
    • , Susan R. Heckbert
    • , Stefan Kääb
    • , John D. Rioux
    • , Eric A. Whitsel
    • , Gonneke Willemsen
    • , Alexander Teumer
    • , David Siscovick
    • , Charles Kooperberg
    • , Cees A. Swenne
    • , Katarzyna Stolarz-Skrzypek
    • , Johannes H. Smit
    • , Alan B. Zonderman
    • , Jean-Claude Tardif
    • , Moritz F. Sinner
    • , Jerome I. Rotter
    • , Kirk C. Wilhelmsen
    • , Marjo-Riitta Järvelin
    • , Quenna Wong
    • , Caroline M. Nievergelt
    • , Nona Sotoodehnia
    • , Tamar Sofer
    • , Marcel den Hoed
    • , Johan Sundström
    • , Andreas Voss
    • , Konstantin Strauch
    • , Bianca J. J. M. Brundel
    • , André G. Uitterlinden
    • , Elsayed Z. Soliman
    • , Ann-Christine Syvänen
    • , Harold Snieder
    • , Erik Ingelsson
    • , Zhu-Ming Zhang
    • , Terho Lehtimäki
    • , Mika Kivimaki
    • , Brenda Penninx
    • , Victoria B. Risbrough
    • , Kent D. Taylor
    • , Bruno H. Stricker
    • , Lars Lind
    • , Melanie Waldenberger
    • , Alexander P. Reiner
    • , Harriëtte Riese
    • , Daniele Cusi
    • , Olli T. Raitakari
    • , Lesley E. Tinker
    • , Henning Tiemeier
    • , Albertine J. Oldehinkel
    • , Adrienne M. Stilp
    • , Phyllis K. Stein
    •  & Diana Kuh

News and Comment