Cardiology

Definition

Cardiology is a medical specialty that is concerned with the structure and function of the heart and vasculature, and the diagnosis and treatment of patients with cardiovascular diseases.

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Latest Research and Reviews

  • Research | | open

    MicroRNA-29 is known to reduce collagen production in fibroblasts thereby inhibiting fibrosis in various organs. Here, Sassi et al. show that miR-29 can also enhance fibrotic signalling and pathological hypertrophy of the heart through its action in cardiomyocytes.

    • Yassine Sassi
    • , Petros Avramopoulos
    • , Deepak Ramanujam
    • , Laurenz Grüter
    • , Stanislas Werfel
    • , Simon Giosele
    • , Andreas-David Brunner
    • , Dena Esfandyari
    • , Aikaterini S. Papadopoulou
    • , Bart De Strooper
    • , Norbert Hübner
    • , Regalla Kumarswamy
    • , Thomas Thum
    • , Xiaoke Yin
    • , Manuel Mayr
    • , Bernhard Laggerbauer
    •  & Stefan Engelhardt
  • Research | | open

    The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • , Thiago S. Mosqueiro
    • , Brian J. Archer
    • , William M. Jones
    • , Hannah Sunshine
    • , Guido C. Faas
    • , Anais Briot
    • , Raquel L. Aragón
    • , Trent Su
    • , Milagros C. Romay
    • , Austin I. McDonald
    • , Cheng-Hsiang Kuo
    • , Carlos O. Lizama
    • , Timothy F. Lane
    • , Ann C. Zovein
    • , Yun Fang
    • , Elizabeth J. Tarling
    • , Thomas Q. de Aguiar Vallim
    • , Mohamad Navab
    • , Alan M. Fogelman
    • , Louis S. Bouchard
    •  & M. Luisa Iruela-Arispe
  • Research | | open

    • Yue Shen
    • , Valerio Russo
    • , Matthew R. Zeglinski
    • , Stephanie L. Sellers
    • , Zhengguo Wu
    • , Cameron Oram
    • , Stephanie Santacruz
    • , Yulia Merkulova
    • , Christopher Turner
    • , Keerit Tauh
    • , Hongyan Zhao
    • , Tatjana Bozin
    • , Lubos Bohunek
    • , Haishan Zeng
    • , Michael A. Seidman
    • , R. Chris Bleackley
    • , Bruce M. McManus
    • , Erkki Ruoslahti
    • , Tero A. H. Järvinen
    •  & David J. Granville
  • Reviews |

    Ischaemic injury during an acute myocardial infarction (AMI) event is followed by an intense inflammatory response that occurs after reperfusion. The inflammasome is a protein complex involved in the regulation of this inflammatory response. In this Review, Toldo and Abbate summarize evidence supporting the therapeutic value of inflammasome-targeted strategies in the context of AMI.

    • Stefano Toldo
    •  & Antonio Abbate
  • Reviews |

    Conduction system disorders lead to slow heart rates that are insufficient to support the circulation, necessitating implantation of electronic pacemakers. Current pacemakers, although effective, have limitations including lead malfunction, lack of autonomic responsiveness, and device-related infections. In this Review, Marbán and colleagues discuss next-generation electronic devices designed to address current limitations, as well as biological pacemakers as alternatives to implantable hardware.

    • Eugenio Cingolani
    • , Joshua I. Goldhaber
    •  & Eduardo Marbán
  • Research |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller

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