Cancer models

Cancer models are naturally existing or artificially induced systems that share features with human cancers. Experimental systems for studying human cancer include cell lines and organisms such as fruit flies and genetically modified mice to investigate cancer biochemical or genetic pathways and pathology.

Latest Research and Reviews

News and Comment

  • Correspondence |

    • Ethan B. Ludmir
    • , Anita Mahajan
    • , Verity Ahern
    • , Thankamma Ajithkumar
    • , Claire Alapetite
    • , Valérie Bernier-Chastagner
    • , Ranjit S. Bindra
    • , Andrew J. Bishop
    • , Stephanie Bolle
    • , Paul D. Brown
    • , Christian Carrie
    • , Anthony J. Chalmers
    • , Eric L. Chang
    • , Caroline Chung
    • , Karin Dieckmann
    • , Natia Esiashvili
    • , Lorenza Gandola
    • , Amol J. Ghia
    • , Vinai Gondi
    • , David R. Grosshans
    • , Semi B. Harrabi
    • , Gail Horan
    • , Danny J. Indelicato
    • , Rakesh Jalali
    • , Geert O. Janssens
    • , Mechthild Krause
    • , Nadia N. Laack
    • , Normand Laperriere
    • , Anne Laprie
    • , Jing Li
    • , Karen J. Marcus
    • , Susan L. McGovern
    • , Thomas E. Merchant
    • , Kenneth W. Merrell
    • , Laetitia Padovani
    • , Jeannette Parkes
    • , Arnold C. Paulino
    • , Rudolf Schwarz
    • , Helen A. Shih
    • , Luis Souhami
    • , Erik P. Sulman
    • , Roger E. Taylor
    • , Nicola Thorp
    • , Beate Timmermann
    • , Greg Wheeler
    • , Suzanne L. Wolden
    • , Kristina D. Woodhouse
    • , Debra N. Yeboa
    • , Torunn I. Yock
    • , Rolf-Dieter Kortmann
    •  & Mary Frances McAleer
  • Correspondence |

    • Kenneth Aldape
    • , Kevin M. Brindle
    • , Louis Chesler
    • , Rajesh Chopra
    • , Amar Gajjar
    • , Mark R. Gilbert
    • , Nicholas Gottardo
    • , David H. Gutmann
    • , Darren Hargrave
    • , Eric C. Holland
    • , David T. W. Jones
    • , Johanna A. Joyce
    • , Pamela Kearns
    • , Mark W. Kieran
    • , Ingo K. Mellinghoff
    • , Melinda Merchant
    • , Stefan M. Pfister
    • , Steven M. Pollard
    • , Vijay Ramaswamy
    • , Jeremy N. Rich
    • , Giles W. Robinson
    • , David H. Rowitch
    • , John H. Sampson
    • , Michael D. Taylor
    • , Paul Workman
    •  & Richard J. Gilbertson
  • Research Highlights |

    In a study published in Nature, Messal, Alt et al. report the use of a new imaging technique that has shed light on the morphology of developing tumours within pancreatic ducts.

    • Sarah Seton-Rogers
  • Research Highlights |

    Ruscetti, Leibold, Bott et al. show that the growth of Kras-mutant lung tumours is sensitive to combined blockade of KRAS effectors. This was dependent on induction of the senescence-activated phenotype in cancer cells, followed by natural killer cell-mediated cell clearance.

    • Ulrike Harjes
    Nature Reviews Cancer 19, 128-129
  • Research Highlights |

    Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.

    • Anna Dart
    Nature Reviews Cancer 19, 126-127