Calcium and phosphate metabolic disorders

Calcium and phosphate metabolic disorders are disorders that are characterized by abnormalities in the processing of calcium or phosphate. These disorders can affect the absorption, transport, storage and use of these minerals. Examples include hypocalcaemia and hyperphosphataemia.

Latest Research and Reviews

Research | 16 January 2019

Effects of drugs on bone metabolism in a cohort of individuals with traumatic spinal cord injury
- Christina Kokorelis
- , Marlis Gonzalez-Fernandez
- , Marjorie Morgan
- & Cristina Sadowsky
Spinal Cord Series and Cases 5, 3
Reviews | 04 December 2018

Renal and extrarenal effects of fibroblast growth factor 23

Fibroblast growth factor 23 (FGF23) regulates phosphate homeostasis by modulating renal phosphate absorption, vitamin D metabolism and parathyroid hormone secretion. In this Review, Marc Vervloet discusses the role of FGF23 on phosphate regulation as well as its additional effects in the cardiovascular and immune systems.
- Marc Vervloet
Nature Reviews Nephrology 15, 109-120
Reviews | 30 November 2018

Tetrahydrobipterin-responsive phenylalanine hydroxylase deficiency
- Shigeo Kure
- & Haruo Shintaku
Journal of Human Genetics 64, 67-71
Reviews | 19 November 2018

The Klotho proteins in health and disease

Klotho proteins are crucial elements of the receptor complex for the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. In this Review, Makoto Kuro-o discusses the functions of the FGF–Klotho endocrine systems in health and disease, including their role in ageing-related disorders.
- Makoto Kuro-o
Nature Reviews Nephrology 15, 27-44
Research | 16 November 2018 | open

Genetic engineering a large animal model of human hypophosphatasia in sheep
- Diarra K. Williams
- , Carlos Pinzón
- , Shannon Huggins
- , Jane H. Pryor
- , Alyssa Falck
- , Forrest Herman
- , James Oldeschulte
- , Michael B. Chavez
- , Brian L. Foster
- , Sarah H. White
- , Mark E. Westhusin
- , Larry J. Suva
- , Charles R. Long
- & Dana Gaddy
Scientific Reports 8, 16945
Research | 18 October 2018 | open

Alendronate release from calcium phosphate cement for bone regeneration in osteoporotic conditions
- Claire I. A. van Houdt
- , Paulo R. Gabbai-Armelin
- , Paula M. Lopez-Perez
- , Dietmar J. O. Ulrich
- , John A. Jansen
- , Ana Claudia M. Renno
- & Jeroen J. J. P. van den Beucken
Scientific Reports 8, 15398