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Three-dimensional (3D) priming, which encapsulates human adipose derived stem cells into hydrogel systems, greatly reduces the amount of time required to induce an efficient retroviral transduction compared with the conventional two-dimensional (2D) method. This facilitating effect is closely related to the acceleration of cell cycle regulation (G1 arrest and G1/S transition) by 3D priming.
We produced a human recombinant Hsp70-1A fused with the cell-penetrating peptide Tat (Tat-Hsp70-1A), that was neuroprotective in vitro against the dopaminergic toxin 6-hydroxydopamine (6-OHDA). We developed and characterized a Tat-Hsp70-1A delivery system by exploiting an injectable, biocompatible, biodegradable semi-interpenetrating polymer network composed of collagen (COLL) and low-molecular-weight hyaluronic acid (LMW HA), structured with gelatin particles. Tat-Hsp70-1A diffused from the selected COLL-LMW HA composites in an active form and protected dopaminergic cells and neurons in Parkinson’s disease (PD) models. Furthermore, Tat-Hsp70-loaded composites conveyed neuroprotection both at behavioral and dopaminergic neuronal level against striatal injection of 6-OHDA.
Touch technology holds potential for the development of smartphones and touchscreens, yet the conventional devices are usually built on separate pressure and location sensing units. Kim et al. show a flexible and transparent touch sensor capable of mapping the position and pressure at the same time.
The advent of ‘big data’ and modern analytics mandates a change of scale in every aspect of the biomedical enterprise. These forces are realigning academic medicine and traditional industrial partners, and also creating the context for an emerging new ecosystem for discovery, translation, care and implementation that promises to transform and integrate all these areas of endeavour.