Central control of bone remodelling articles from across Nature Portfolio

Latest Research and Reviews

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  3′-Sialyllactose alleviates bone loss by regulating bone homeostasis

  3′-Sialyllactose alleviates the progression of osteoporosis by regulating bone homeostasis and may have a therapeutic effect as an anti-osteoporosis agent.

  • Ahreum Baek
  • Dawoon Baek
  • Sung-Rae Cho

  ResearchOpen Access19 Jan 2024 Communications Biology

  Volume: 7, P: 110
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  Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts

  Despite the importance of osteoclast secretory lysosomes in bone digestion, the proteins that regulate them remain ill defined. Here, the authors identify Slc37a2 as a secretory lysosome sugar transporter that is required for maintenance of skeletal bone mass.

  • Pei Ying Ng
  • Amy B. P. Ribet
  • Nathan J. Pavlos

  ResearchOpen Access21 Feb 2023 Nature Communications

  Volume: 14, P: 906
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  Commensal gut bacterium critically regulates alveolar bone homeostasis

  Commensal microbe effects on alveolar bone homeostasis have been attributed to the oral microbiota, yet the impact of commensal gut microbes is unknown. Studies performed with segmented filamentous bacteria (SFB) monoassociated mice revealed commensal gut microbes modulate osteoimmune responses and skeletal homeostasis in alveolar bone. This work challenges the current paradigm that alveolar bone health is strictly regulated by oral microbes.

  • Jessica D. Hathaway-Schrader
  • Matthew D. Carson
  • Chad M. Novince

  Research21 Dec 2021 Laboratory Investigation

  Volume: 102, P: 363-375
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  Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineages

  • Belén Prados
  • Raquel del Toro
  • José Luis de la Pompa

  ResearchOpen Access22 Jul 2021 Cell Death & Disease

  Volume: 12, P: 729
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  Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity

  Mutations in human PIEZO2, encoding for a mechanosensitive ion channel, lead to skeletal abnormalities including scoliosis and hip dysplasia. Here, the authors show that deletion of Piezo2 in proprioceptive neurons, but not in skeletal lineages, recapitulated the human phenotype in mice.

  • Eran Assaraf
  • Ronen Blecher
  • Elazar Zelzer

  ResearchOpen Access23 Jun 2020 Nature Communications

  Volume: 11, P: 3168
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  Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway

  • Qi Cui
  • Jinhao Xing
  • Hongshan Zhao

  ResearchOpen Access20 Feb 2019 Cell Death & Disease

  Volume: 10, P: 172