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Bone marrow is the tissue that fills the cavities of bones. Bone marrow exists in two types: yellow and red. Yellow marrow consists mostly of fat cells whereas red marrow is a haematopoietic tissue involved in producing erythrocytes and leukocytes.
Lymphocytes are on high demand during chronic infections. Here, the authors show that human lymphoid precursors, normally found in the bone marrow, circulate in the blood of chronic inflammation patients and give rise to natural killer cells and other lymphocytes.
Soluble urokinase plasminogen activator receptor (suPAR) is a circulating biomarker of inflammation. A recent study identifies immature myeloid cells in the bone marrow as a major cellular source of suPAR that contributes to kidney disease.
Two anatomical niches for hematopoietic stem cells (HSCs) have been reported in the
bone marrow, but a distinct function for each of these niches has remained unclear. A new
role in stem cell proliferation has now been identified for the adhesion molecule E-selectin
expressed by bone marrow endothelial cells at the vascular niche (pages 1651–1657).