Bladder disease


Bladder disease is an umbrella term used to describe pathological conditions that affect the structure or function of the bladder. Bladder diseases include conditions related to inflammation, infection and urinary incontinence.

Latest Research and Reviews

  • Reviews |

    In this Review, the authors describe the role of the NO–sGC–cGMP signalling pathway in disease pathophysiology of urogenital tissue. They discuss advances in directly targeting sGC to enhance cGMP production independently using NO-independent stimulators and activators of sGC and the potential of these molecules for treating urogenital disorders.

    • Fabiola Z. Mónica
    •  & Edson Antunes
  • Reviews |

    Urinary incontinence symptoms in women are prevalent and substantially affect health-related quality of life. These issues are compounded by the limited attention that urinary incontinence receives at the policy or research-funding levels. Despite these challenges, the field has witnessed considerable innovations in practice over the past decade, which are summarized in this Primer.

    • Yoshitaka Aoki
    • , Heidi W. Brown
    • , Linda Brubaker
    • , Jean Nicolas Cornu
    • , J. Oliver Daly
    •  & Rufus Cartwright
  • Reviews |

    The risk of urinary incontinence and other lower urinary tract (LUT) symptoms increases substantially with advancing age; however, such symptoms can emerge in otherwise healthy individuals. In this Review, the authors describe the changes in LUT physiology that take place during the ageing process, and whether or not these changes arise as a consequence of 'normal', healthy ageing, or unaddressed pathology.

    • William Gibson
    •  & Adrian Wagg
  • Reviews |

    A substantial number of women have pelvic floor dysfunction, resulting in urinary and/or faecal incontinence, often many years after vaginal delivery. In this Review, the authors describe the potential of regenerative medicine to repair and regenerate pelvic floor muscles and thus prevent, or ameliorate the symptoms of pelvic floor dysfunction.

    • Geertje Callewaert
    • , Marina Monteiro Carvalho Mori Da Cunha
    • , Nikhil Sindhwani
    • , Maurilio Sampaolesi
    • , Maarten Albersen
    •  & Jan Deprest
  • Reviews |

    Overactive bladder in children is a surprisingly common syndrome that can persist into adulthood. Evidence increasingly suggests that this syndrome can be explained by neurological changes or comorbidities. Here, the author describes the causes, symptoms and management of paediatric patients with overactive bladder.

    • Israel Franco

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