Biotechnology

Biotechnology is a broad discipline in which biological processes, organisms, cells or cellular components are exploited to develop new technologies. New tools and products developed by biotechnologists are useful in research, agriculture, industry and the clinic.

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Latest Research and Reviews

  • Research |

    Current high-throughput 3′ single-cell RNA-sequencing (scRNA-seq) techniques are limited in their ability to elucidate the variable sequences of antigen receptors. Love and colleagues describe a strategy that enables simultaneous analysis of TCR sequences and the corresponding full transcriptomes from 3′-barcoded scRNA-seq samples.

    • Ang A. Tu
    • , Todd M. Gierahn
    • , Brinda Monian
    • , Duncan M. Morgan
    • , Naveen K. Mehta
    • , Bert Ruiter
    • , Wayne G. Shreffler
    • , Alex K. Shalek
    •  & J. Christopher Love
    Nature Immunology 20, 1692-1699
  • Research
    | Open Access

    • Mark J. McCabe
    • , Marie-Emilie A. Gauthier
    • , Chia-Ling Chan
    • , Tanya J. Thompson
    • , Sunita M.C. De Sousa
    • , Clare Puttick
    • , John P. Grady
    • , Velimir Gayevskiy
    • , Jiang Tao
    • , Kevin Ying
    • , Arcadi Cipponi
    • , Niantao Deng
    • , Alex Swarbrick
    • , Melissa L. Thomas
    • , Reginald V. Lord
    • , Amber L. Johns
    • , Maija Kohonen-Corish
    • , Sandra A. O’Toole
    • , Jonathan Clark
    • , Simon A. Mueller
    • , Ruta Gupta
    • , Ann I. McCormack
    • , Marcel E. Dinger
    • , Mark J. Cowley
    • , Morteza Aghmesheh
    • , David Amor
    • , Lesley Andrews
    • , Yoland Antill
    • , Shane Armitage
    • , Leanne Arnold
    • , Rosemary Balleine
    • , Patti Bastick
    • , Jonathan Beesley
    • , John Beilby
    • , Ian Bennett
    • , Anneke Blackburn
    • , Michael Bogwitz
    • , Leon Botes
    • , Meagan Brennan
    • , Melissa Brown
    • , Michael Buckley
    • , Matthew Burgess
    • , Jo Burke
    • , Phyllis Butow
    • , Liz Caldon
    • , David Callen
    • , Ian Campbell
    • , Deepa Chauhan
    • , Manisha Chauhan
    • , Georgia Chenevix-Trench
    • , Alice Christian
    • , Christine Clarke
    • , Paul Cohen
    • , Alison Colley
    • , Ashley Crook
    • , James Cui
    • , Bronwyn Culling
    • , Margaret Cummings
    • , Sarah-Jane Dawson
    • , Anna deFazio
    • , Martin Delatycki
    • , Rebecca Dickson
    • , Joanne Dixon
    • , Alexander Dobrovic
    • , Tracy Dudding
    • , Ted Edkins
    • , Stacey Edwards
    • , Maurice Eisenbruch
    • , Gelareh Farshid
    • , Andrew Fellows
    • , Georgina Fenton
    • , Michael Field
    • , James Flanagan
    • , Peter Fong
    • , Laura Forrest
    • , Stephen Fox
    • , Juliet French
    • , Michael Friedlander
    • , Clara Gaff
    • , Davi Gallego Ortega
    • , Mike Gattas
    • , Peter George
    • , Graham Giles
    • , Grantley Gill
    • , Sian Greening
    • , Eric Haan
    • , Marion Harris
    • , Stewart Hart
    • , Nick Hayward
    • , Louise Heiniger
    • , John Hopper
    • , Clare Hunt
    • , Paul James
    • , Mark Jenkins
    • , Rick Kefford
    • , Alexa Kidd
    • , Judy Kirk
    • , Jessica Koehler
    • , James Kollias
    • , Sunil Lakhani
    • , Geoff Lindeman
    • , Lara Lipton
    • , Liz Lobb
    • , Graham Mann
    • , Deborah Marsh
    • , Sue Ann McLachaln
    • , Bettina Meiser
    • , Roger Milne
    • , Sophie Nightingale
    • , Shona O’Connell
    • , Sarah O’Sullivan
    • , Nick Pachter
    • , Briony Patterson
    • , Kelly Phillips
    • , Ellen Pieper
    • , Edwina Rickard
    • , Bridget Robinson
    • , Mona Saleh
    • , Elizabeth Salisbury
    • , Joe Sambrook
    • , Christobel Saunders
    • , Jodi Saunus
    • , Elizabeth Scott
    • , Clare Scott
    • , Rodney Scott
    • , Adrienne Sexton
    • , Andrew Shelling
    • , Peter Simpson
    • , Melissa Southey
    • , Amanda Spurdle
    • , Jessica Taylor
    • , Heather Thorne
    • , Alison Trainer
    • , Kathy Tucker
    • , Jane Visvader
    • , Logan Walker
    • , Rachael Williams
    • , Ingrid Winship
    •  & Mary-Anne Young
  • Research
    | Open Access

    Multiplexed genome engineering with Cas9 can increase efficiency but also the risk of unintended alterations. Here the authors demonstrate the use of multiplexed base editors on primary T cells with reduced translocation frequency.

    • Beau R. Webber
    • , Cara-lin Lonetree
    • , Mitchell G. Kluesner
    • , Matthew J. Johnson
    • , Emily J. Pomeroy
    • , Miechaleen D. Diers
    • , Walker S. Lahr
    • , Garrett M. Draper
    • , Nicholas J. Slipek
    • , Branden S. Smeester
    • , Klaus N. Lovendahl
    • , Amber N. McElroy
    • , Wendy R. Gordon
    • , Mark J. Osborn
    •  & Branden S. Moriarity

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