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Biosurfaces are synthetic surfaces that are coated with biological materials and/or are designed to have a specific biological function or application. They are important in areas such as sensing and the detection of diseases.
This protocol describes a solvent-assisted method to prepare supported lipid bilayers (SLBs) with minimal sample preparation. The approach is quick, easy to implement, and compatible with a wide range of lipid compositions and material supports.
Vibrational energy relaxation of proteins helps us to understand ultrafast protein dynamics. Here, the authors determine the vibrational energy transfer time of the amide I mode in aqueous environment and find that water provides a “shortcut” through a direct resonant channel to dissipate energy into the solvent.
N-succinimidyl monomers such as N-methacryloxysuccinimide (MASI) and N-acryloxysuccinimide (ASI) were utilized as prepolymers to synthesize glycopolymers via postpolymerization modification. Living radical polymerization with RAFT agents succeeded using not only MASI but also ASI. While the polymerization with ATRP initiator did not succeed using ASI, the procedure was successful with MASI. MASI was also applicable for SI-ATRP reactions on substrate surfaces. The introduction rate of NH2-terminated saccharide onto the prepolymer via amine coupling reaction was affected by the reaction temperature. This preparation procedure via postpolymerization modification is expected to provide a facile method for various functional polymers, such as other saccharide and beneficial ligands.