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Biomaterials are those materials — be it natural or synthetic, alive or lifeless, and usually made of multiple components — that interact with biological systems. Biomaterials are often used in medical applications to augment or replace a natural function.
Metallic stents have been widely used in coronary angioplasty. Here, the authors develop a resorbable self-expanding stent from polymeric elastomers with high mechanical strength for coronary applications.
Biocatalysis, if selective, offers great potential for the well-controlled release of drugs and other payloads. Here, Minko and co-workers separate enzymes and substrates by loading them onto individual, polymer-coated nanoparticles, and show that a magnetic field switches on the catalytic activity by merging the polymer shells.
Ice crystal growth is a major problem in cell and tissue cryopreservation for transplantation, transfusion, icing of aircraft wings and many other applications. Here the authors review the emerging field of synthetic macromolecular mimics of antifreeze proteins that can be used overcome such problems.
Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.