Biological models

Biological models are experimental systems that recreate aspects of human tissue function or disease. For example, certain tumour cell lines may serve as cancer models, and transgenic mice that express human beta-amyloid protein may serve as animal models of Alzheimer’s disease.

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  • Research Highlights |

    Ruscetti, Leibold, Bott et al. show that the growth of Kras-mutant lung tumours is sensitive to combined blockade of KRAS effectors. This was dependent on induction of the senescence-activated phenotype in cancer cells, followed by natural killer cell-mediated cell clearance.

    • Ulrike Harjes
  • News and Views |

    Vaccination with the tuberculosis (TB) vaccine Bacillus Calmette–Guérin (BCG) into the lungs of Rhesus macaques induces specific, local immune responses that delay infection in some animals and completely prevent it in others while protecting against TB disease.

    • Thomas J. Scriba
    •  & Elisa Nemes
    Nature Medicine 25, 199-201
  • Research Highlights |

    Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.

    • Anna Dart