Bioconjugate chemistry

Bioconjugate chemistry is the study of linking one molecule to another by chemical or biological means. The resulting complexes will typically be formed from at least one biomolecule, though they can also be purely synthetic molecules with a biological application.

Latest Research and Reviews

News and Comment

  • News and Views |

    Ribosomes have now been shown to accept certain initiator tRNAs acylated with aromatic foldamer–dipeptides thereby enabling the translation of a peptide or protein with a short aromatic foldamer at the N-terminus. Some foldamer–peptide hybrids could be cyclized to generate macrocycles that present conformationally restricted peptide loops.

    • Alanna Schepartz
    Nature Chemistry 10, 377-379
  • News and Views |

    Protein drugs are important therapies for many different diseases, but very few can be administered orally. Now, a cationic dendronized polymer has been shown to stabilize a therapeutic protein for delivery to the gut.

    • Heather D. Maynard
    Nature Chemistry 5, 557-558
  • News and Views |

    A new type of protein–polymer conjugate provides improved stability without detrimentally affecting bioactivity, and thus offers great potential for the development of new peptide-based drugs.

    • Matthew C. Parrott
    •  & Joseph M. DeSimone
    Nature Chemistry 4, 13-14