Biochemical networks

Biochemical networks are abstract graphs in which biological molecules such as enzymes or metabolites are represented by nodes, which are connected when two molecules interact physically or functionally. Such models allow one to make complex predictions about cellular functions that would not be accessible from single-molecule studies.

Latest Research and Reviews

News and Comment

  • News and Views |

    Bacterial communication is a potential strategy to control bacterial behaviours and thus, attenuate pathogen infectivity; however, identifying the signalling molecules that regulate communication pathways is challenging. Now, a robust strategy to rapidly identify previously unknown signalling peptides has been developed. This approach provides a means to map out and decipher bacterial signalling mechanisms.

    • Dominic N. McBrayer
    •  & Yftah Tal-Gan
    Nature Chemistry 11, 398-399
  • News and Views |

    Attempts to build lifelike synthetic protocells must consider extracellular influences in order to accurately reflect the behaviours and characteristics of real ecosystems. Now, this concept has been demonstrated by the synthesis of a community of protocells in which one cell type preys upon another.

    • Sheref S. Mansy
    Nature Chemistry 9, 107-108
  • Comments and Opinion |

    • Philippe Bastiaens
    • , Marc R Birtwistle
    • , Nils Blüthgen
    • , Frank J Bruggeman
    • , Kwang-Hyun Cho
    • , Carlo Cosentino
    • , Alberto de la Fuente
    • , Jan B Hoek
    • , Anatoly Kiyatkin
    • , Steffen Klamt
    • , Walter Kolch
    • , Stefan Legewie
    • , Pedro Mendes
    • , Takashi Naka
    • , Tapesh Santra
    • , Eduardo Sontag
    • , Hans V Westerhoff
    •  & Boris N Kholodenko
    Nature Biotechnology 33, 336-339