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Physiologically relevant ligands for mammalian odorant receptors have been elusive. A mouse odorant receptor–based bioassay has now been used to guide purification and identification of a natural ligand that mediates attraction of female mice to male urine.
A new high-throughput method for monitoring G protein–coupled receptor activation is highly suited to assaying Gα12/13-coupled receptors and is used to deorphanize a group of receptors activated by lysophosphatidylserine.