Bioanalytical chemistry

Bioanalytical chemistry is a subdiscipline of analytical chemistry that involves the separation, detection, identification and quantification of biological samples in different settings. It often involves the study of molecules such as proteins, peptides, DNA and drugs.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Bacteria sense metal ions using proteins whose interactions with DNA are sensitive to metal ion availability and identity. Less competitive metal ions trigger protein–DNA binding only at high concentrations.

    • David Schilter
  • Research Highlights |

    Following binding kinetics over time rather than relying on differences in free-energy of binding enables detection of single molecules of mutant DNA with an estimated specificity of 99.99999%.

    • Stephen G. Davey
  • Research Highlights |

    This study identifies a human antibody fragment that recognizes i-motifs and shows that these DNA structures are present in the nuclei of human cells.

    • Katharine H Wrighton
  • News and Views |

    A method for directly probing binding interactions in free solution, without the need for chemical tagging, offers exciting opportunities for non-perturbative analyses of biomolecules in their native state.

    • Enrique Valera
    •  & Ryan C. Bailey
    Nature Chemistry 7, 767-769
  • News and Views |

    An electrochemical clamp assay that enables the rapid and sensitive detection of nucleic acids containing single base mutations has now been developed. It has been shown to differentiate between cancer patient samples featuring a specific mutation, and controls from healthy donors or other cancer patients, all directly in unprocessed serum.

    • Irina A. Gorodetskaya
    •  & Alon A. Gorodetsky
    Nature Chemistry 7, 541-542