Bioanalytical chemistry


Bioanalytical chemistry is a subdiscipline of analytical chemistry that involves the separation, detection, identification and quantification of biological samples in different settings. It often involves the study of molecules such as proteins, peptides, DNA and drugs.

Latest Research and Reviews

News and Comment

  • News and Views |

    A method for directly probing binding interactions in free solution, without the need for chemical tagging, offers exciting opportunities for non-perturbative analyses of biomolecules in their native state.

    • Enrique Valera
    •  & Ryan C. Bailey
    Nature Chemistry 7, 767–769
  • News and Views |

    An electrochemical clamp assay that enables the rapid and sensitive detection of nucleic acids containing single base mutations has now been developed. It has been shown to differentiate between cancer patient samples featuring a specific mutation, and controls from healthy donors or other cancer patients, all directly in unprocessed serum.

    • Irina A. Gorodetskaya
    •  & Alon A. Gorodetsky
    Nature Chemistry 7, 541–542
  • News and Views |

    Oxidation of 5-methylcytosine has been proposed to mediate active and passive DNA demethylation. Tracking the history of DNA modifications has now provided the first solid evidence that 5-hydroxymethylcytosine is a stable epigenetic modification.

    • Pijus Brazauskas
    •  & Skirmantas Kriaucionis
    Nature Chemistry 6, 1031–1033
  • News and Views |

    An extracellular ejection of zinc, known as a zinc spark, is triggered by the fertilization of a mammalian egg; however, the origin of this zinc was not clear. Now, a combination of four complementary techniques has revealed the source and provided an unprecedented quantification of the distribution of zinc in a maturing mammalian oocyte.

    • Kyle P. Carter
    •  & Amy E. Palmer
    Nature Chemistry 7, 96–97