Bacterial synthetic biology

Bacterial synthetic biology is a scientific discipline that deals with the synthesis of part, or the whole, of bacteria that do not exist in nature in this form. It uses engineering and molecular biology tools.

Latest Research and Reviews

News and Comment

  • News and Views |

    Only a tiny fraction of bacterial species can be cultured and engineered in the laboratory, limiting our ability to deploy bacteria in harsh environments or use them to produce important compounds. Recent work has opened this frontier by developing new methods to characterize and engineer diverse, undomesticated bacterial species.

    • Elizabeth A. Libby
    •  & Pamela A. Silver
    Nature Microbiology 4, 212-213
  • News and Views |

    Commensal microbes engineered to convert natural compounds found in cruciferous vegetables into molecules with anticancer properties prevent carcinogenesis and cause the regression of colorectal cancer in mice fed with a vegetable diet.

    • David A. Drew
    •  & Andrew T. Chan
  • News and Views |

    The incorporation of additional gene circuits into hosts can often lead to unpredicted and undesirable behaviours. Recent work has developed a modelling framework that accounts for host–circuit interactions and can predict a variety of phenotypes at both single-cell and population levels.

    • Sandra J. Aedo
    • , Grant Gelderman
    •  & Mark P. Brynildsen
    Nature Microbiology 2, 1584-1585
  • News and Views |

    Co-culture of bacterial cells engineered with quorum-sensing and self-lysis circuits allows coupled oscillatory dynamics and stable states, opening the way to engineered microbial ecosystems with targeted dynamics and extending gene circuits to the ecosystem level.

    • Alfonso Jaramillo