Bacterial pathogenesis articles from across Nature Portfolio

In Mycobacterium tuberculosis, the fitness cost of rifampicin resistance is partially due to excessive RNA polymerase pausing and is rescued by mutations in the pro-pausing transcription factor NusG.

Bacterial type IV pili are filamentous cell surface structures and candidate targets for vaccine development. Here, authors determine how antibodies interact with pili at the structural level providing insight into immune escape mechanisms and potential countermeasures.

A comprehensive study reveals that the two-component system BfmRS senses high osmotic stress and transcriptionally activates the expression of siderophore genes, which is essential for environmental adaption of P. aeruginosa.

In this study, Fu et al. show that Streptococcus anginosus promotes gastric tumorigenesis in mice.

This study reports a mechanism whereby a Staphylococcus aureus protease induces itch by activating a host receptor on sensory neurons in the skin.

This study reports that intracellular cord formation by Mycobacterium tuberculosis is an important feature of early pathogenesis.

In this study, Sharafutdinov et al. report a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is associated with gastric cancer.

In this study, Douglas et al. examine the role of the staphylococcal TcaA protein in human serum susceptibility during bacteraemia.

This study provides insights into the mechanism whereby Citrobacter rodentium transitions from the intestinal lumen to its mucosal niche.