Bacterial immune evasion

Definition

Bacterial immune evasion is the process by which bacteria avoid and antagonize the bacterial host response, which is mediated by the host's immune system.

Latest Research and Reviews

News and Comment

  • News and Views |

    The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

    • Madeleine W. Cunningham
    Nature Microbiology 2, 1334–1335
  • News and Views |

    Attaching and effacing enteropathogenic Escherichia coli causes gastrointestinal inflammation and diarrhoea. In this issue of Nature Microbiology, Pearson and colleagues find that this pathology involves bacterial cleavage of a class of host cell death signal adaptors that encode a unique protein interaction motif called the RHIM.

    • Thiago DeSouza-Vieira
    •  & Francis Ka-Ming Chan
  • News and Views |

    Sequence variability in microbial surface proteins can be extensive in order to promote immune escape, but the changes must not interfere with the function of the protein. Structural analysis of a streptococcal protein now clarifies how an extremely variable region retains its ability to specifically bind its human target.

    • Gunnar Lindahl
    •  & Jenny J. Persson
  • News and Views |

    Some urologists might be surprised that the urinary tract is not sterile, and bacteria might have important roles in a number of urological conditions such as urge incontinence. This paradigm shift, which has been further illustrated by data from a recent study, has implications for how urologists diagnose disease and treat patients.

    • Gregor Reid
    •  & Jeremy P. Burton