Autoimmune diseases

Autoimmune diseases are a pathophysiological state wherein immune responses are directed against, and damage, the body's own tissues (autoimmunity). Common examples of autoimmune disease include type 1 diabetes, rheumatoid arthritis, multiple sclerosis and psoriasis.

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Latest Research and Reviews

  • Research | | open

    Genome-wide association studies (GWAS) have so far uncovered more than 200 loci for multiple sclerosis (MS). Here, the authors integrate data from various sources for a cell type-specific pathway analysis of MS GWAS results that specifically highlights the involvement of the immune system in disease pathogenesis.

    • Lohith Madireddy
    • , Niklaos A. Patsopoulos
    • , Chris Cotsapas
    • , Steffan D. Bos
    • , Ashley Beecham
    • , Jacob McCauley
    • , Kicheol Kim
    • , Xiaoming Jia
    • , Adam Santaniello
    • , Stacy J. Caillier
    • , Till F. M. Andlauer
    • , Lisa F. Barcellos
    • , Tone Berge
    • , Luisa Bernardinelli
    • , Filippo Martinelli-Boneschi
    • , David R. Booth
    • , Farren Briggs
    • , Elisabeth G. Celius
    • , Manuel Comabella
    • , Giancarlo Comi
    • , Bruce A. C. Cree
    • , Sandra D’Alfonso
    • , Katrina Dedham
    • , Pierre Duquette
    • , Dardiotis Efthimios
    • , Federica Esposito
    • , Bertrand Fontaine
    • , Christiane Gasperi
    • , An Goris
    • , Bénédicte Dubois
    • , Pierre-Antoine Gourraud
    • , Georgios Hadjigeorgiou
    • , Jonathan Haines
    • , Clive Hawkins
    • , Bernhard Hemmer
    • , Rogier Hintzen
    • , Dana Horakova
    • , Noriko Isobe
    • , Seema Kalra
    • , Jun-ichi Kira
    • , Michael Khalil
    • , Ingrid Kockum
    • , Christina M. Lill
    • , Matthew R. Lincoln
    • , Felix Luessi
    • , Roland Martin
    • , Annette Oturai
    • , Aarno Palotie
    • , Margaret A. Pericak-Vance
    • , Roland Henry
    • , Janna Saarela
    • , Adrian Ivinson
    • , Tomas Olsson
    • , Bruce V. Taylor
    • , Graeme J. Stewart
    • , Hanne F. Harbo
    • , Alastair Compston
    • , Stephen L. Hauser
    • , David A. Hafler
    • , Frauke Zipp
    • , Philip De Jager
    • , Stephen Sawcer
    • , Jorge R. Oksenberg
    •  & Sergio E. Baranzini
  • Research | | open

    Giuliana Lania, Merlin Nanayakkara et al. show that cells from celiac disease patients have delays in early endocytic trafficking and an increase sensitivity to gliadin peptide P31-43. Delaying early vesicular trafficking in control cells induces a celiac-like cellular phenotype, highlighting a role for the early-recycling endosomal system in celiac disease.

    • Giuliana Lania
    • , Merlin Nanayakkara
    • , Mariantonia Maglio
    • , Renata Auricchio
    • , Monia Porpora
    • , Mariangela Conte
    • , Maria Antonietta De Matteis
    • , Riccardo Rizzo
    • , Alberto Luini
    • , Valentina Discepolo
    • , Riccardo Troncone
    • , Salvatore Auricchio
    •  & Maria Vittoria Barone
  • Reviews |

    Type 1 diabetes is an autoimmune disease that causes the destruction of pancreatic β-cells, which results in an insulin deficiency. In this Review, the authors discuss immunomodulatory biomaterials for β-cell replacement and for the induction of tolerogenic immune responses to prevent, delay or reverse the disease.

    • C. L. Stabler
    • , Y. Li
    • , J. M. Stewart
    •  & B. G. Keselowsky
  • Research | | open

    Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

    • Simon H. Jiang
    • , Vicki Athanasopoulos
    • , Julia I. Ellyard
    • , Aaron Chuah
    • , Jean Cappello
    • , Amelia Cook
    • , Savit B. Prabhu
    • , Jacob Cardenas
    • , Jinghua Gu
    • , Maurice Stanley
    • , Jonathan A. Roco
    • , Ilenia Papa
    • , Mehmet Yabas
    • , Giles D. Walters
    • , Gaetan Burgio
    • , Kathryn McKeon
    • , James M. Byers
    • , Charlotte Burrin
    • , Anselm Enders
    • , Lisa A. Miosge
    • , Pablo F. Canete
    • , Marija Jelusic
    • , Velibor Tasic
    • , Adrian C. Lungu
    • , Stephen I. Alexander
    • , Arthur R. Kitching
    • , David A. Fulcher
    • , Nan Shen
    • , Todor Arsov
    • , Paul A. Gatenby
    • , Jeff J. Babon
    • , Dominic F. Mallon
    • , Carmen de Lucas Collantes
    • , Eric A. Stone
    • , Philip Wu
    • , Matthew A. Field
    • , Thomas D. Andrews
    • , Eun Cho
    • , Virginia Pascual
    • , Matthew C. Cook
    •  & Carola G. Vinuesa

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