Autoimmune diseases

Definition

Autoimmune diseases are a pathophysiological state wherein immune responses are directed against, and damage, the body's own tissues (autoimmunity). Common examples of autoimmune disease include type 1 diabetes, rheumatoid arthritis, multiple sclerosis and psoriasis.

Featured

Latest Research and Reviews

  • Reviews |

    Inadequate remyelination is central to degeneration and disability in patients with multiple sclerosis (MS); however, all currently approved therapies for MS are primarily immunomodulatory. Here, Martin Stangel and colleagues review our current knowledge of remyelination in MS, discuss results from clinical trials of remyelination-enhancing therapies, and evaluate the opportunities for future regenerative treatments.

    • Martin Stangel
    • , Tanja Kuhlmann
    • , Paul M. Matthews
    •  & Trevor J. Kilpatrick
  • Reviews |

    Promoting remyelination may be an effective therapeutic strategy for various disorders that are characterized by a loss of myelin, including multiple sclerosis. In this Review, Franklin and ffrench-Constant discuss recent developments in our understanding of remyelination and the efforts that are underway to enhance this process.

    • Robin J. M. Franklin
    •  & Charles ffrench-Constant
  • Research |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller
  • Research | | open

    CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.

    • Dan Hu
    • , Samuele Notarbartolo
    • , Tom Croonenborghs
    • , Bonny Patel
    • , Ron Cialic
    • , Tun-Hsiang Yang
    • , Dominik Aschenbrenner
    • , Karin M. Andersson
    • , Marco Gattorno
    • , Minh Pham
    • , Pia Kivisakk
    • , Isabelle V. Pierre
    • , Youjin Lee
    • , Karun Kiani
    • , Maria Bokarewa
    • , Emily Tjon
    • , Nathalie Pochet
    • , Federica Sallusto
    • , Vijay K. Kuchroo
    •  & Howard L. Weiner
  • Research | | open

    Osteoclasts are involved in arthritis, and their differentiation depends on RANKL signaling. The author show that the ROS-scavenging protein DJ-1 negatively regulates RANKL signaling and that its ablation increases osteoclast numbers and exacerbates bone damage in mouse models of arthritis.

    • Hyuk Soon Kim
    • , Seung Taek Nam
    • , Se Hwan Mun
    • , Sun-Kyeong Lee
    • , Hyun Woo Kim
    • , Young Hwan Park
    • , Bokyung Kim
    • , Kyung-Jong Won
    • , Hae-Rim Kim
    • , Yeong-Min Park
    • , Hyung Sik Kim
    • , Michael A. Beaven
    • , Young Mi Kim
    •  & Wahn Soo Choi
  • Reviews |

    The symptomatic pre-arthritis phase of rheumatoid arthritis (RA) is hypothesized to be part of a 'window of opportunity' for preventive treatment. This Review discusses the methodological considerations when designing and interpreting preventive trials, and translating findings into clinical practice.

    • Hanna W. van Steenbergen
    • , José A. Pereira da Silva
    • , Tom W. J. Huizinga
    •  & Annette H. M. van der Helm-van Mil

News and Comment