Atopic dermatitis

Definition

Atopic dermatitis, also known as atopic eczema, is a chronic inflammatory familial disease of the skin. It is characterized by an increased ability to form immunoglobulin E and a tendency to develop other allergic conditions such as allergic rhinitis and asthma.

Latest Research and Reviews

  • Research |

    Erwin Gelfand, Andrew Snow, Joshua Milner and colleagues identify heterozygous CARD11 mutations associated with severe atopic disease in eight individuals from four families. They further show that the mutant CARD11 proteins exhibit both loss-of-function and dominant-interfering activity and that the cellular defects in patient T cells can be partially rescued by supplementing with glutamine.

    • Chi A Ma
    • , Jeffrey R Stinson
    • , Yuan Zhang
    • , Jordan K Abbott
    • , Michael A Weinreich
    • , Pia J Hauk
    • , Paul R Reynolds
    • , Jonathan J Lyons
    • , Celeste G Nelson
    • , Elisa Ruffo
    • , Batsukh Dorjbal
    • , Salomé Glauzy
    • , Natsuko Yamakawa
    • , Swadhinya Arjunaraja
    • , Kelsey Voss
    • , Jennifer Stoddard
    • , Julie Niemela
    • , Yu Zhang
    • , Sergio D Rosenzweig
    • , Joshua J McElwee
    • , Thomas DiMaggio
    • , Helen F Matthews
    • , Nina Jones
    • , Kelly D Stone
    • , Alejandro Palma
    • , Matías Oleastro
    • , Emma Prieto
    • , Andrea R Bernasconi
    • , Geronimo Dubra
    • , Silvia Danielian
    • , Jonathan Zaiat
    • , Marcelo A Marti
    • , Brian Kim
    • , Megan A Cooper
    • , Neil Romberg
    • , Eric Meffre
    • , Erwin W Gelfand
    • , Andrew L Snow
    •  & Joshua D Milner
    Nature Genetics 49, 1192–1201
  • Research | | open

    TWEAK is a TNF family member that binds the NFκB signalling receptor Fn14. Here the authors show that TWEAK is central to skin inflammation in mouse models of atopic dermatitis and psoriasis and causes similar pathology when injected subcutaneously into mice.

    • Daniel Sidler
    • , Ping Wu
    • , Rana Herro
    • , Meike Claus
    • , Dennis Wolf
    • , Yuko Kawakami
    • , Toshiaki Kawakami
    • , Linda Burkly
    •  & Michael Croft
  • Research | | open

    DOCK8-deficiency can cause atopic dermatitis but the mechanism is unclear. Here the authors use mice and human samples to show ARNT-independent DOCK8 inhibition of EPAS1 increases transcription of IL-31 in CD4+ T cells, thus driving skin inflammation.

    • Kazuhiko Yamamura
    • , Takehito Uruno
    • , Akira Shiraishi
    • , Yoshihiko Tanaka
    • , Miho Ushijima
    • , Takeshi Nakahara
    • , Mayuki Watanabe
    • , Makiko Kido-Nakahara
    • , Ikuya Tsuge
    • , Masutaka Furue
    •  & Yoshinori Fukui
  • Reviews |

    Inflammatory conditions such as asthma, atopic dermatitis and chronic sinusitis with nasal polyps are caused by type 2 inflammation. In this Review, Gandhi et al. explore the idea that these conditions can be treated by targeting the common proximal drivers of type 2 inflammation, which include interleukin-4 (IL-4), IL-5 and IL-13, and discuss the supporting clinical evidence as well as candidate drugs in development.

    • Namita A. Gandhi
    • , Brandy L. Bennett
    • , Neil M. H. Graham
    • , Gianluca Pirozzi
    • , Neil Stahl
    •  & George D. Yancopoulos
  • Research |

    Lavinia Paternoster and colleagues report the results of a large, multi-ancestry genome-wide association study of atopic dermatitis. They identify ten new susceptibility loci harboring candidate genes involved in innate host defense and T cell function.

    • the EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium
    • , Lavinia Paternoster
    • , Marie Standl
    • , Johannes Waage
    • , Hansjörg Baurecht
    • , Melanie Hotze
    • , David P Strachan
    • , John A Curtin
    • , Klaus Bønnelykke
    • , Chao Tian
    • , Atsushi Takahashi
    • , Jorge Esparza-Gordillo
    • , Alexessander Couto Alves
    • , Jacob P Thyssen
    • , Herman T den Dekker
    • , Manuel A Ferreira
    • , Elisabeth Altmaier
    • , Patrick M A Sleiman
    • , Feng Li Xiao
    • , Juan R Gonzalez
    • , Ingo Marenholz
    • , Birgit Kalb
    • , Maria Pino-Yanes
    • , Cheng-Jian Xu
    • , Lisbeth Carstensen
    • , Maria M Groen-Blokhuis
    • , Cristina Venturini
    • , Craig E Pennell
    • , Sheila J Barton
    • , Albert M Levin
    • , Ivan Curjuric
    • , Mariona Bustamante
    • , Eskil Kreiner-Møller
    • , Gabrielle A Lockett
    • , Jonas Bacelis
    • , Supinda Bunyavanich
    • , Rachel A Myers
    • , Anja Matanovic
    • , Ashish Kumar
    • , Joyce Y Tung
    • , Tomomitsu Hirota
    • , Michiaki Kubo
    • , Wendy L McArdle
    • , A John Henderson
    • , John P Kemp
    • , Jie Zheng
    • , George Davey Smith
    • , Franz Rüschendorf
    • , Anja Bauerfeind
    • , Min Ae Lee-Kirsch
    • , Andreas Arnold
    • , Georg Homuth
    • , Carsten O Schmidt
    • , Elisabeth Mangold
    • , Sven Cichon
    • , Thomas Keil
    • , Elke Rodríguez
    • , Annette Peters
    • , Andre Franke
    • , Wolfgang Lieb
    • , Natalija Novak
    • , Regina Fölster-Holst
    • , Momoko Horikoshi
    • , Juha Pekkanen
    • , Sylvain Sebert
    • , Lise L Husemoen
    • , Niels Grarup
    • , Johan C de Jongste
    • , Fernando Rivadeneira
    • , Albert Hofman
    • , Vincent W V Jaddoe
    • , Suzanne G M A Pasmans
    • , Niels J Elbert
    • , André G Uitterlinden
    • , Guy B Marks
    • , Philip J Thompson
    • , Melanie C Matheson
    • , Colin F Robertson
    • , Janina S Ried
    • , Jin Li
    • , Xian Bo Zuo
    • , Xiao Dong Zheng
    • , Xian Yong Yin
    • , Liang Dan Sun
    • , Maeve A McAleer
    • , Grainne M O'Regan
    • , Caoimhe M R Fahy
    • , Linda E Campbell
    • , Milan Macek
    • , Michael Kurek
    • , Donglei Hu
    • , Celeste Eng
    • , Dirkje S Postma
    • , Bjarke Feenstra
    • , Frank Geller
    • , Jouke Jan Hottenga
    • , Christel M Middeldorp
    • , Pirro Hysi
    • , Veronique Bataille
    • , Tim Spector
    • , Ronny Myhre
    • , Elisabeth Thiering
    • , Hans Bisgaard
    • , Scott Huntsman
    • , Scott T Weiss
    • , Nicholas G Martin
    • , Wenche Nystad
    • , Badri Pahukasahasram
    • , James J Yang
    • , Daniel Glass
    • , Jordi Sunyer
    • , Allan Linneberg
    • , Norbert Hübner
    • , John W Holloway
    • , Benjamin A Raby
    • , Mads Melbye
    • , Erik Melén
    • , Joachim Heinrich
    • , Dorret I Boomsma
    • , Nicole M Probst-Hensch
    • , David M Evans
    • , Medea Imboden
    • , Angela Simpson
    • , Natàlia Vilor-Tejedor
    • , Bo Jacobsson
    • , Carla M T Tiesler
    • , Young-Ae Lee
    • , Caroline L Relton
    • , Markus M Nöthen
    • , Mayumi Tamari
    • , Sara J Brown
    • , Keith M Godfrey
    • , Deborah A Meyers
    • , Liesbeth Duijts
    • , Gerard H Koppelman
    • , W H Irwin McLean
    • , Adnan Custovic
    • , Susanne Lau
    • , Alan D Irvine
    • , Deborah Jarvis
    • , Xue Jun Zhang
    • , Stephan Weidinger
    • , Carol A Wang
    • , Marjo-Riitta Jarvelin
    • , Esteban G Burchard
    • , Cilla Söderhäll
    • , L Keoki Williams
    • , Christian Gieger
    • , Hakon Hakonarson
    • , Carole Ober
    •  & David A Hinds
    Nature Genetics 47, 1449–1456

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