Atherosclerosis

Atherosclerosis is the thickening and loss of elasticity of the walls of arteries that is associated with the formation of atherosclerotic plaques within the arterial intima. Inflammation has an important role in the pathology of atherosclerosis.

Latest Research and Reviews

  • Research | | open

    Men and women differ in their risk of developing coronary artery disease, in part due to differences in their levels of sex hormones. Here, AlSiraj et al. show that the XX sex genotype regulates lipid metabolism and promotes atherosclerosis independently of sex hormones in mice.

    • Yasir AlSiraj
    • , Xuqi Chen
    • , Sean E. Thatcher
    • , Ryan E. Temel
    • , Lei Cai
    • , Eric Blalock
    • , Wendy Katz
    • , Heba M. Ali
    • , Michael Petriello
    • , Pan Deng
    • , Andrew J. Morris
    • , Xuping Wang
    • , Aldons J. Lusis
    • , Arthur P. Arnold
    • , Karen Reue
    • , Katherine Thompson
    • , Patrick Tso
    •  & Lisa A. Cassis
  • Reviews |

    ST-segment elevation myocardial infarction (STEMI) is an acute coronary syndrome in which transmural ischaemia (mostly caused by the formation of a thrombus on a ruptured atherosclerotic plaque) leads to cardiomyocyte death. STEMI is associated with considerable morbidity and mortality worldwide.

    • Birgit Vogel
    • , Bimmer E. Claessen
    • , Suzanne V. Arnold
    • , Danny Chan
    • , David J. Cohen
    • , Evangelos Giannitsis
    • , C. Michael Gibson
    • , Shinya Goto
    • , Hugo A. Katus
    • , Mathieu Kerneis
    • , Takeshi Kimura
    • , Vijay Kunadian
    • , Duane S. Pinto
    • , Hiroki Shiomi
    • , John A. Spertus
    • , P. Gabriel Steg
    •  & Roxana Mehran
  • Research |

    Histone H4 is released from neutrophil extracellular traps and induces membrane lysis in vascular smooth muscle cells, leading to the destabilization of atherosclerotic plaques.

    • Carlos Silvestre-Roig
    • , Quinte Braster
    • , Kanin Wichapong
    • , Ernest Y. Lee
    • , Jean Marie Teulon
    • , Nihel Berrebeh
    • , Janine Winter
    • , José M. Adrover
    • , Giancarlo Santiago Santos
    • , Alexander Froese
    • , Patricia Lemnitzer
    • , Almudena Ortega-Gómez
    • , Raphael Chevre
    • , Julian Marschner
    • , Ariane Schumski
    • , Carla Winter
    • , Laura Perez-Olivares
    • , Chang Pan
    • , Nicole Paulin
    • , Tom Schoufour
    • , Helene Hartwig
    • , Silvia González-Ramos
    • , Frits Kamp
    • , Remco T. A. Megens
    • , Kerri A. Mowen
    • , Matthias Gunzer
    • , Lars Maegdefessel
    • , Tilman Hackeng
    • , Esther Lutgens
    • , Mat Daemen
    • , Julia von Blume
    • , Hans-Joachim Anders
    • , Viacheslav O. Nikolaev
    • , Jean-Luc Pellequer
    • , Christian Weber
    • , Andrés Hidalgo
    • , Gerry A. F. Nicolaes
    • , Gerard C. L. Wong
    •  & Oliver Soehnlein
    Nature 569, 236-240

News and Comment