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Archaeal physiology is the scientific study of the life-supporting functions and processes of Archaea, a domain of organisms that comprise single, nucleus-free cells, distinct from bacteria and eukaryotes.
Activity-based protein profiling (ABPP) is a chemical proteomics method to profile activity states of enzymes under physiological conditions. Here the authors show that ABPP can be applied to archaeal serine hydrolases in the model organism Sulfolobus acidocaldarius and can be used to identify novel putative serine hydrolases.
Crystal structures of the Argonaute protein from the archaeon Methanocaldococcus jannaschii (MjAgo) in its apo state and bound to a guide DNA elucidate the molecular mechanisms that drive DNA-guided DNA silencing in Archaea.
Structural and functional studies of the archaeum Methanocaldococcus jannaschii Argonaute (MjAgo) reveal a DNA-guided DNA nuclease that is also active without a guide. This unguided activity is suggested to prime MjAgo for its subsequent sequence-specific DNA-silencing role in host defence.